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Enhancing CDK4/6 inhibitor therapy for medulloblastoma using nanoparticle delivery and scRNA-seq-guided combination with sapanisertib
Chaemin Lim, Taylor Dismuke, Daniel Malawsky, Jacob D. Ramsey, Duhyeong Hwang, Virginia L. Godfrey, Alexander V. Kabanov, Timothy R. Gershon, Marina Sokolsky-Papkov
doi: https://doi.org/10.1101/2021.06.09.447757
Chaemin Lim
1Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, U.S.A
Taylor Dismuke
2Department of Pathology, UNC School of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
Daniel Malawsky
3Department of Neurology, UNC School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
4Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Jacob D. Ramsey
1Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, U.S.A
Duhyeong Hwang
1Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, U.S.A
Virginia L. Godfrey
4Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Alexander V. Kabanov
1Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, U.S.A
5Laboratory of Chemical Design of Bionanomaterials, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, 119992, Russia
Timothy R. Gershon
3Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK
6Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
7Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
Marina Sokolsky-Papkov
1Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, U.S.A
Posted June 22, 2021.
Enhancing CDK4/6 inhibitor therapy for medulloblastoma using nanoparticle delivery and scRNA-seq-guided combination with sapanisertib
Chaemin Lim, Taylor Dismuke, Daniel Malawsky, Jacob D. Ramsey, Duhyeong Hwang, Virginia L. Godfrey, Alexander V. Kabanov, Timothy R. Gershon, Marina Sokolsky-Papkov
bioRxiv 2021.06.09.447757; doi: https://doi.org/10.1101/2021.06.09.447757
Enhancing CDK4/6 inhibitor therapy for medulloblastoma using nanoparticle delivery and scRNA-seq-guided combination with sapanisertib
Chaemin Lim, Taylor Dismuke, Daniel Malawsky, Jacob D. Ramsey, Duhyeong Hwang, Virginia L. Godfrey, Alexander V. Kabanov, Timothy R. Gershon, Marina Sokolsky-Papkov
bioRxiv 2021.06.09.447757; doi: https://doi.org/10.1101/2021.06.09.447757
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