Myofilament Glycation in Diabetes Reduces Contractility by Inhibiting Tropomyosin Movement, is Rescued by cMyBPC Domains

Maria Papadaki; Theerachat Kampaengsri; Samantha K. Barrick; Stuart G. Campbell; Dirk von Lewinski; Peter P. Rainer; Samantha P. Harris; Michael J. Greenberg; Jonathan A. Kirk

doi:10.1101/2021.06.09.447778

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Myofilament Glycation in Diabetes Reduces Contractility by Inhibiting Tropomyosin Movement, is Rescued by cMyBPC Domains

Maria Papadaki, Theerachat Kampaengsri, Samantha K. Barrick, View ORCID ProfileStuart G. Campbell, Dirk von Lewinski, Peter P. Rainer, Samantha P. Harris, View ORCID ProfileMichael J. Greenberg, View ORCID ProfileJonathan A. Kirk

doi: https://doi.org/10.1101/2021.06.09.447778

Maria Papadaki

1Department of Cell and Molecular Physiology, Loyola University of Chicago, Maywood, Illinois, USA

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Theerachat Kampaengsri

1Department of Cell and Molecular Physiology, Loyola University of Chicago, Maywood, Illinois, USA

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Samantha K. Barrick

2Department of Biochemistry and Molecular Biophysics, Washington University in St Louis, St Louis, Missouri, USA

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Stuart G. Campbell

3Department of Bioengineering, Yale University, New Haven, Connecticut, USA

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Dirk von Lewinski

4Division of Cardiology, Medical University of Graz, Graz, Austria

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Peter P. Rainer

4Division of Cardiology, Medical University of Graz, Graz, Austria

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Samantha P. Harris

5Department of Cellular and Molecular Medicine, The University of Arizona, Tucson, Arizona, USA

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Michael J. Greenberg

2Department of Biochemistry and Molecular Biophysics, Washington University in St Louis, St Louis, Missouri, USA

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Jonathan A. Kirk

1Department of Cell and Molecular Physiology, Loyola University of Chicago, Maywood, Illinois, USA

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For correspondence: jkirk2@luc.edu

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Myofilament Glycation in Diabetes Reduces Contractility by Inhibiting Tropomyosin Movement, is Rescued by cMyBPC Domains

Maria Papadaki, Theerachat Kampaengsri, Samantha K. Barrick, Stuart G. Campbell, Dirk von Lewinski, Peter P. Rainer, Samantha P. Harris, Michael J. Greenberg, Jonathan A. Kirk

bioRxiv 2021.06.09.447778; doi: https://doi.org/10.1101/2021.06.09.447778

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Myofilament Glycation in Diabetes Reduces Contractility by Inhibiting Tropomyosin Movement, is Rescued by cMyBPC Domains

Maria Papadaki, Theerachat Kampaengsri, Samantha K. Barrick, Stuart G. Campbell, Dirk von Lewinski, Peter P. Rainer, Samantha P. Harris, Michael J. Greenberg, Jonathan A. Kirk

bioRxiv 2021.06.09.447778; doi: https://doi.org/10.1101/2021.06.09.447778

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