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A chemical strategy toward novel brain-penetrant EZH2 inhibitors
Rui Liang, Daisuke Tomita, Yusuke Sasaki, John Ginn, Mayako Michino, David J. Huggins, Leigh Baxt, Stacia Kargman, Maaz Shahid, Kazuyoshi Aso, Mark Duggan, Andrew W. Stamford, Elisa DeStanchina, Nigel Liverton, Peter T. Meinke, Michael A. Foley, Richard E. Phillips
doi: https://doi.org/10.1101/2021.06.10.447852
Rui Liang
1Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY, 10021, USA
Daisuke Tomita
1Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY, 10021, USA
Yusuke Sasaki
1Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY, 10021, USA
John Ginn
1Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY, 10021, USA
Mayako Michino
1Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY, 10021, USA
David J. Huggins
1Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY, 10021, USA
2Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10021, USA
Leigh Baxt
1Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY, 10021, USA
Stacia Kargman
1Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY, 10021, USA
Maaz Shahid
6Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
7Epigenetics Program, Perelman School of Medicine, Philadelphia, PA 19104, USA
8Abramson Cancer Center, Perelman School of Medicine, Philadelphia, PA 19104, USA
Kazuyoshi Aso
1Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY, 10021, USA
Mark Duggan
3LifeSci Consulting, LLC. 18243 SE Ridgeview Drive, Tequesta, FL 33469, USA
Andrew W. Stamford
1Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY, 10021, USA
Elisa DeStanchina
4Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Nigel Liverton
1Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY, 10021, USA
Peter T. Meinke
1Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY, 10021, USA
5Department of Pharmacology, Weill Cornell Medical College, New York, NY 10021, USA
Michael A. Foley
1Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY, 10021, USA
Richard E. Phillips
6Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
7Epigenetics Program, Perelman School of Medicine, Philadelphia, PA 19104, USA
8Abramson Cancer Center, Perelman School of Medicine, Philadelphia, PA 19104, USA
Posted June 10, 2021.
A chemical strategy toward novel brain-penetrant EZH2 inhibitors
Rui Liang, Daisuke Tomita, Yusuke Sasaki, John Ginn, Mayako Michino, David J. Huggins, Leigh Baxt, Stacia Kargman, Maaz Shahid, Kazuyoshi Aso, Mark Duggan, Andrew W. Stamford, Elisa DeStanchina, Nigel Liverton, Peter T. Meinke, Michael A. Foley, Richard E. Phillips
bioRxiv 2021.06.10.447852; doi: https://doi.org/10.1101/2021.06.10.447852
A chemical strategy toward novel brain-penetrant EZH2 inhibitors
Rui Liang, Daisuke Tomita, Yusuke Sasaki, John Ginn, Mayako Michino, David J. Huggins, Leigh Baxt, Stacia Kargman, Maaz Shahid, Kazuyoshi Aso, Mark Duggan, Andrew W. Stamford, Elisa DeStanchina, Nigel Liverton, Peter T. Meinke, Michael A. Foley, Richard E. Phillips
bioRxiv 2021.06.10.447852; doi: https://doi.org/10.1101/2021.06.10.447852
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