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MGEnrichment: a web application for microglia gene list enrichment analysis

View ORCID ProfileJustin Jao, View ORCID ProfileAnnie Vogel Ciernia
doi: https://doi.org/10.1101/2021.06.10.447854
Justin Jao
Biochemistry and Molecular Biology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver Canada, 2215 Wesbrook Mall, Vancouver, BC V6T2A1, Canada
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Annie Vogel Ciernia
Biochemistry and Molecular Biology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver Canada, 2215 Wesbrook Mall, Vancouver, BC V6T2A1, Canada
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  • For correspondence: annie.ciernia@ubc.ca
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Abstract

Gene expression analysis is becoming increasingly utilized in neuro-immunology research, and there is a growing need for non-programming scientists to be able to analyze their own genomic data. MGEnrichment is a web application developed both to disseminate to the community our curated database of microglia-relevant gene lists, and to allow non-programming scientists to easily conduct statistical enrichment analysis on their gene expression data. Users can upload their own gene IDs to assess the relevance of their expression data against gene lists from other studies. We include example datasets of differentially expressed genes (DEGs) from human postmortem brain samples from Autism Spectrum Disorder (ASD) and matched controls. We demonstrate how MGEnrichment can be used to expand the interpretations of these DEG lists in terms of regulation of microglial gene expression and provide novel insights into how ASD DEGs may be implicated specifically in microglial development, microbiome responses and relationships to other neuropsychiatric disorders. This tool will be particularly useful for those working in microglia, autism spectrum disorders, and neuro-immune activation research. MGEnrichment is available at https://ciernialab.shinyapps.io/MGEnrichmentApp/ and further online documentation and datasets can be found at https://github.com/ciernialab/MGEnrichmentApp. The app is released under the GNU GPLv3 open source license.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted June 10, 2021.
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MGEnrichment: a web application for microglia gene list enrichment analysis
Justin Jao, Annie Vogel Ciernia
bioRxiv 2021.06.10.447854; doi: https://doi.org/10.1101/2021.06.10.447854
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MGEnrichment: a web application for microglia gene list enrichment analysis
Justin Jao, Annie Vogel Ciernia
bioRxiv 2021.06.10.447854; doi: https://doi.org/10.1101/2021.06.10.447854

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