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Safety and Potency of COVIran Barekat Inactivated Vaccine Candidate for SARS-CoV-2: A Preclinical Study

Asghar Abdoli, Reza Aalizadeh, Hossein Aminianfar, Zahra Kianmehr, Ebrahim Azimi, Nabbi Emamipour, Hamidreza Jamshidi, Mohammadreza Hosseinpour, Mohammad Taqavian, Hasan Jalili
doi: https://doi.org/10.1101/2021.06.10.447951
Asghar Abdoli
1Pasteur Institute of Iran, Department of Hepatitis and AIDS, Tehran, Iran
2Amirabad Virology laboratory, Vaccine Unit, Tehran, Iran
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Reza Aalizadeh
3Biochemistry Department, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran
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  • For correspondence: aalizadehreza19@gmail.com Hjalili@ut.ac.ir
Hossein Aminianfar
4Institute of Biomedical Research, University of Tehran, Tehran, Iran
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Zahra Kianmehr
5Department of Biochemistry, Faculty of Biological Science, North Tehran Branch, Islamic Azad University, Tehran, Iran
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Ebrahim Azimi
6Department of Biotechnology, Darou Pakhsh Pharmaceutical co., Tehran, Iran
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Nabbi Emamipour
6Department of Biotechnology, Darou Pakhsh Pharmaceutical co., Tehran, Iran
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Hamidreza Jamshidi
7Secretary of the National Headquarters for Fighting Corona Virus, Ministry of Health and Medical Education, Iran
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Mohammadreza Hosseinpour
8Biopharmaceutical Consultant at Pharma Engineering co, Tehran, Iran
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Mohammad Taqavian
9Biosunpharmed Co. Tehran, Iran
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Hasan Jalili
10Department of life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
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  • For correspondence: aalizadehreza19@gmail.com Hjalili@ut.ac.ir
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Abstract

There is an urgent demand to manufacture an effective and safe vaccine to prevent SARS-CoV2 infection, which resulted in a global pandemic. In this study, we developed an inactivated whole-virus SARS-CoV-2 candidate vaccine named COVIran Barekat. Immunization at two different doses (3 µg or 5 µg per dose) elicited a high level of SARS-CoV-2 specific neutralizing antibodies in mice, rabbits, and non-human primates. The results show the safety profile in studied animals (include guinea pig, rabbit, mice, and monkeys). Rhesus macaques were immunized with the two-dose of 5 µg and 3 µg of the COVIran Barekat vaccine and showed highly efficient protection against 104 TCID50 of SARS-CoV-2 intratracheal challenge compared with the control group. These results highlight the COVIran Barekat vaccine as a potential candidate to induce a strong and potent immune response which may be a promising and feasible vaccine to protect against SARS-CoV2 infection.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 10, 2021.
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Safety and Potency of COVIran Barekat Inactivated Vaccine Candidate for SARS-CoV-2: A Preclinical Study
Asghar Abdoli, Reza Aalizadeh, Hossein Aminianfar, Zahra Kianmehr, Ebrahim Azimi, Nabbi Emamipour, Hamidreza Jamshidi, Mohammadreza Hosseinpour, Mohammad Taqavian, Hasan Jalili
bioRxiv 2021.06.10.447951; doi: https://doi.org/10.1101/2021.06.10.447951
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Safety and Potency of COVIran Barekat Inactivated Vaccine Candidate for SARS-CoV-2: A Preclinical Study
Asghar Abdoli, Reza Aalizadeh, Hossein Aminianfar, Zahra Kianmehr, Ebrahim Azimi, Nabbi Emamipour, Hamidreza Jamshidi, Mohammadreza Hosseinpour, Mohammad Taqavian, Hasan Jalili
bioRxiv 2021.06.10.447951; doi: https://doi.org/10.1101/2021.06.10.447951

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