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Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers
Joshua T. Lange, Celine Y. Chen, Yuriy Pichugin, Liangqi Xie, Jun Tang, King L. Hung, Kathryn E. Yost, Quanming Shi, Marcella L. Erb, Utkrisht Rajkumar, Sihan Wu, Charles Swanton, Zhe Liu, Weini Huang, Howard Y. Chang, Vineet Bafna, Anton G. Henssen, Benjamin Werner, Paul S. Mischel
doi: https://doi.org/10.1101/2021.06.11.447968
Joshua T. Lange
1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
2ChEM-H, Stanford University, Stanford, CA, USA
Celine Y. Chen
3Department of Pediatric Oncology/Hematology, Charité—Universitätsmedizin Berlin, Berlin, Germany
Yuriy Pichugin
4Department of Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Plon, Germany
Liangqi Xie
5Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA
6Department of Molecular and Cell Biology, Li Ka Shing Center for Biomedical and Health Sciences, CIRM Center of Excellence, University of California, Berkeley, CA, USA
Jun Tang
1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
2ChEM-H, Stanford University, Stanford, CA, USA
King L. Hung
7Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA
Kathryn E. Yost
7Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA
Quanming Shi
7Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA
Marcella L. Erb
8UCSD Light Microscopy Core Facility, Department of Neurosciences, University of California San Diego, La Jolla, CA, USA
Utkrisht Rajkumar
9Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA
Sihan Wu
1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
2ChEM-H, Stanford University, Stanford, CA, USA
Charles Swanton
10Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK
11Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK
12Department of Medical Oncology, University College London Hospitals, London, UK
Zhe Liu
5Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA
Weini Huang
13Group of Theoretical Biology, The State Key Laboratory of Biocontrol, School of Life Science, Sun Yat-sen University, Guangzhou, China
14Department of Mathematics, Queen Mary University of London, London, UK
Howard Y. Chang
7Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA
15Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA
Vineet Bafna
9Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA
Anton G. Henssen
3Department of Pediatric Oncology/Hematology, Charité—Universitätsmedizin Berlin, Berlin, Germany
16Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine and Charité—Universitätsmedizin Berlin, Berlin, Germany
17German Cancer Consortium (DKTK), partner site Berlin, and German Cancer Research Center DKFZ, Heidelberg, Germany
18Berlin Institute of Health, Berlin, Germany
Benjamin Werner
19Evolutionary Dynamics Group, Centre for Cancer Genomics and Computation Biology, Barts Cancer Institute, Queen Mary University of London, London, UK
Paul S. Mischel
1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
2ChEM-H, Stanford University, Stanford, CA, USA
Posted June 11, 2021.
Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers
Joshua T. Lange, Celine Y. Chen, Yuriy Pichugin, Liangqi Xie, Jun Tang, King L. Hung, Kathryn E. Yost, Quanming Shi, Marcella L. Erb, Utkrisht Rajkumar, Sihan Wu, Charles Swanton, Zhe Liu, Weini Huang, Howard Y. Chang, Vineet Bafna, Anton G. Henssen, Benjamin Werner, Paul S. Mischel
bioRxiv 2021.06.11.447968; doi: https://doi.org/10.1101/2021.06.11.447968
Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers
Joshua T. Lange, Celine Y. Chen, Yuriy Pichugin, Liangqi Xie, Jun Tang, King L. Hung, Kathryn E. Yost, Quanming Shi, Marcella L. Erb, Utkrisht Rajkumar, Sihan Wu, Charles Swanton, Zhe Liu, Weini Huang, Howard Y. Chang, Vineet Bafna, Anton G. Henssen, Benjamin Werner, Paul S. Mischel
bioRxiv 2021.06.11.447968; doi: https://doi.org/10.1101/2021.06.11.447968
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