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UK B.1.1.7 variant exhibits increased respiratory replication and shedding in nonhuman primates

View ORCID ProfileK. Rosenke, F. Feldmann, A. Okumura, F. Hansen, T. Tang-Huau, K. Meade-White, B. Kaza, B.J. Smith, P. W. Hanley, J. Lovaglio, M. A. Jarvis, C. Shaia, H. Feldmann
doi: https://doi.org/10.1101/2021.06.11.448134
K. Rosenke
1Laboratory of Virology, Hamilton, MT, Unites States
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F. Feldmann
2Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Hamilton, MT, Unites States
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A. Okumura
1Laboratory of Virology, Hamilton, MT, Unites States
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F. Hansen
1Laboratory of Virology, Hamilton, MT, Unites States
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T. Tang-Huau
1Laboratory of Virology, Hamilton, MT, Unites States
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K. Meade-White
1Laboratory of Virology, Hamilton, MT, Unites States
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B. Kaza
1Laboratory of Virology, Hamilton, MT, Unites States
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B.J. Smith
2Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Hamilton, MT, Unites States
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P. W. Hanley
2Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Hamilton, MT, Unites States
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J. Lovaglio
2Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Hamilton, MT, Unites States
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M. A. Jarvis
1Laboratory of Virology, Hamilton, MT, Unites States
3University of Plymouth; Plymouth, United Kingdom
4The Vaccine Group Ltd; Plymouth, United Kingdom
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C. Shaia
2Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Hamilton, MT, Unites States
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H. Feldmann
1Laboratory of Virology, Hamilton, MT, Unites States
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  • For correspondence: feldmannh@niaid.nih.gov
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Abstract

The continuing emergence of SARS-CoV-2 variants calls for regular assessment to identify differences in viral replication, shedding and associated disease. In this study, African green monkeys were infected intranasally with either a contemporary D614G or the UK B.1.1.7 variant. Both variants caused mild respiratory disease with no significant differences in clinical presentation. Significantly higher levels of viral RNA and infectious virus were found in upper and lower respiratory tract samples and tissues from B.1.1.7 infected animals. Interestingly, D614G infected animals showed significantly higher levels of viral RNA and infectious virus in rectal swabs and gastrointestinal tract tissues. Our results indicate that B.1.1.7 infection in African green monkeys is associated with increased respiratory replication and shedding but no disease enhancement similar to human B.1.1.7 cases.

One-Sentence Summary UK B.1.1.7 infection of African green monkeys exhibits increased respiratory replication and shedding but no disease enhancement

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted June 13, 2021.
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UK B.1.1.7 variant exhibits increased respiratory replication and shedding in nonhuman primates
K. Rosenke, F. Feldmann, A. Okumura, F. Hansen, T. Tang-Huau, K. Meade-White, B. Kaza, B.J. Smith, P. W. Hanley, J. Lovaglio, M. A. Jarvis, C. Shaia, H. Feldmann
bioRxiv 2021.06.11.448134; doi: https://doi.org/10.1101/2021.06.11.448134
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UK B.1.1.7 variant exhibits increased respiratory replication and shedding in nonhuman primates
K. Rosenke, F. Feldmann, A. Okumura, F. Hansen, T. Tang-Huau, K. Meade-White, B. Kaza, B.J. Smith, P. W. Hanley, J. Lovaglio, M. A. Jarvis, C. Shaia, H. Feldmann
bioRxiv 2021.06.11.448134; doi: https://doi.org/10.1101/2021.06.11.448134

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