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Reconstitution of the DTX3L-PARP9 complex reveals determinants for high affinity heterodimer formation and enzymatic function

View ORCID ProfileYashwanth Ashok, Carlos Vela-Rodriguez, Chunsong Yang, Heli I. Alanen, Fan Liu, View ORCID ProfileBryce M. Paschal, View ORCID ProfileLari Lehtiö
doi: https://doi.org/10.1101/2021.06.14.448324
Yashwanth Ashok
1Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Finland
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Carlos Vela-Rodriguez
1Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Finland
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Chunsong Yang
2Department of Biochemistry and Molecular genetics, University of Virginia, PO Box 800577, Charlottesville, VA22908, USA
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Heli I. Alanen
1Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Finland
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Fan Liu
3Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Deutschland
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Bryce M. Paschal
2Department of Biochemistry and Molecular genetics, University of Virginia, PO Box 800577, Charlottesville, VA22908, USA
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Lari Lehtiö
1Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Finland
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  • For correspondence: lari.lehtio@oulu.fi
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Article Information

doi 
https://doi.org/10.1101/2021.06.14.448324
History 
  • October 13, 2021.

Article Versions

  • Version 1 (June 14, 2021 - 20:16).
  • Version 2 (June 22, 2021 - 00:20).
  • You are viewing Version 3, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Yashwanth Ashok1,#&,
  2. Carlos Vela-Rodriguez1,#,
  3. Chunsong Yang2,
  4. Heli I. Alanen1,
  5. Fan Liu3,
  6. Bryce M. Paschal2 and
  7. Lari Lehtiö1,*
  1. 1Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Finland
  2. 2Department of Biochemistry and Molecular genetics, University of Virginia, PO Box 800577, Charlottesville, VA22908, USA
  3. 3Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Deutschland
  1. ↵*Corresponding author: Lari Lehtiö – lari.lehtio{at}oulu.fi
  1. ↵# These authors contributed equally

  • ↵& Dept. of Genome Sciences, University of Washington, Seattle, USA

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Posted October 13, 2021.
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Reconstitution of the DTX3L-PARP9 complex reveals determinants for high affinity heterodimer formation and enzymatic function
Yashwanth Ashok, Carlos Vela-Rodriguez, Chunsong Yang, Heli I. Alanen, Fan Liu, Bryce M. Paschal, Lari Lehtiö
bioRxiv 2021.06.14.448324; doi: https://doi.org/10.1101/2021.06.14.448324
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Reconstitution of the DTX3L-PARP9 complex reveals determinants for high affinity heterodimer formation and enzymatic function
Yashwanth Ashok, Carlos Vela-Rodriguez, Chunsong Yang, Heli I. Alanen, Fan Liu, Bryce M. Paschal, Lari Lehtiö
bioRxiv 2021.06.14.448324; doi: https://doi.org/10.1101/2021.06.14.448324

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