Reconstitution of the DTX3L-PARP9 complex reveals determinants for high affinity heterodimer formation and enzymatic function

Yashwanth Ashok; Carlos Vela-Rodriguez; Chunsong Yang; Heli I. Alanen; Fan Liu; Bryce M. Paschal; Lari Lehtiö

doi:10.1101/2021.06.14.448324

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Reconstitution of the DTX3L-PARP9 complex reveals determinants for high affinity heterodimer formation and enzymatic function

View ORCID ProfileYashwanth Ashok, Carlos Vela-Rodriguez, Chunsong Yang, Heli I. Alanen, Fan Liu, View ORCID ProfileBryce M. Paschal, View ORCID ProfileLari Lehtiö

doi: https://doi.org/10.1101/2021.06.14.448324

Yashwanth Ashok

1Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Finland

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Carlos Vela-Rodriguez

1Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Finland

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Chunsong Yang

2Department of Biochemistry and Molecular genetics, University of Virginia, PO Box 800577, Charlottesville, VA22908, USA

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Heli I. Alanen

1Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Finland

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Fan Liu

3Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Deutschland

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Bryce M. Paschal

2Department of Biochemistry and Molecular genetics, University of Virginia, PO Box 800577, Charlottesville, VA22908, USA

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Lari Lehtiö

1Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Finland

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For correspondence: lari.lehtio@oulu.fi

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Posted October 13, 2021.

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Reconstitution of the DTX3L-PARP9 complex reveals determinants for high affinity heterodimer formation and enzymatic function

Yashwanth Ashok, Carlos Vela-Rodriguez, Chunsong Yang, Heli I. Alanen, Fan Liu, Bryce M. Paschal, Lari Lehtiö

bioRxiv 2021.06.14.448324; doi: https://doi.org/10.1101/2021.06.14.448324

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Reconstitution of the DTX3L-PARP9 complex reveals determinants for high affinity heterodimer formation and enzymatic function

Yashwanth Ashok, Carlos Vela-Rodriguez, Chunsong Yang, Heli I. Alanen, Fan Liu, Bryce M. Paschal, Lari Lehtiö

bioRxiv 2021.06.14.448324; doi: https://doi.org/10.1101/2021.06.14.448324

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