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Lipid nanodiscs facilitate the identification of a fragment compound inhibiting the enzymatic activity of the bacterial membrane protein MsbA
Kaoru Fujimoto, Akinobu Senoo, Satoru Nagatoishi, Daisuke Takahashi, Tadashi Ueda, View ORCID ProfileKouhei Tsumoto, View ORCID ProfileJose M.M. Caaveiro
doi: https://doi.org/10.1101/2021.06.15.448612
Kaoru Fujimoto
1Laboratory of Protein Structure, Function, and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Akinobu Senoo
2Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
Satoru Nagatoishi
3Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
Daisuke Takahashi
1Laboratory of Protein Structure, Function, and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Tadashi Ueda
1Laboratory of Protein Structure, Function, and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Kouhei Tsumoto
2Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
3Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
4Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
Jose M.M. Caaveiro
5Laboratory of Global Healthcare, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Article usage
Posted June 16, 2021.
Lipid nanodiscs facilitate the identification of a fragment compound inhibiting the enzymatic activity of the bacterial membrane protein MsbA
Kaoru Fujimoto, Akinobu Senoo, Satoru Nagatoishi, Daisuke Takahashi, Tadashi Ueda, Kouhei Tsumoto, Jose M.M. Caaveiro
bioRxiv 2021.06.15.448612; doi: https://doi.org/10.1101/2021.06.15.448612
Lipid nanodiscs facilitate the identification of a fragment compound inhibiting the enzymatic activity of the bacterial membrane protein MsbA
Kaoru Fujimoto, Akinobu Senoo, Satoru Nagatoishi, Daisuke Takahashi, Tadashi Ueda, Kouhei Tsumoto, Jose M.M. Caaveiro
bioRxiv 2021.06.15.448612; doi: https://doi.org/10.1101/2021.06.15.448612
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