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A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters
View ORCID ProfileKathryn McGuckin Wuertz, Erica K. Barkei, Wei-Hung Chen, View ORCID ProfileElizabeth J. Martinez, View ORCID ProfileInes Lakhal-Naouar, View ORCID ProfileLinda L. Jagodzinski, View ORCID ProfileDominic Paquin-Proulx, View ORCID ProfileGregory D. Gromowski, View ORCID ProfileIsabella Swafford, View ORCID ProfileAkshaya Ganesh, Ming Dong, View ORCID ProfileXiankun Zeng, Paul V. Thomas, Rajeshwer S. Sankhala, Agnes Hajduczki, Caroline E. Peterson, Caitlin Kuklis, Sandrine Soman, Lindsay Wieczorek, Michelle Zemil, Alexander Anderson, Janice Darden, Heather Hernandez, Hannah Grove, View ORCID ProfileVincent Dussupt, Holly Hack, Rafael de la Barrera, Stasya Zarling, James F. Wood, Jeffrey W. Froude, Matthew Gagne, Amy R. Henry, Elham Bayat Mokhtari, View ORCID ProfilePrakriti Mudvari, Shelly J. Krebs, View ORCID ProfileAndrew S. Pekosz, Jeffrey R. Currier, View ORCID ProfileSwagata Kar, Maciel Porto, Adrienne Winn, Kamil Radzyminski, Mark G. Lewis, Sandhya Vasan, View ORCID ProfileMehul Suthar, Victoria R. Polonis, View ORCID ProfileGary R. Matyas, View ORCID ProfileEli A. Boritz, Daniel C. Douek, Robert A. Seder, Sharon P. Daye, Mangala Rao, Sheila A. Peel, M. Gordon Joyce, View ORCID ProfileDiane L. Bolton, Nelson L. Michael, View ORCID ProfileKayvon Modjarrad
doi: https://doi.org/10.1101/2021.06.16.448525
Kathryn McGuckin Wuertz
1U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Erica K. Barkei
2Veterinary Pathology Division, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Wei-Hung Chen
3Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Elizabeth J. Martinez
3Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Ines Lakhal-Naouar
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
5Diagnostics Countermeasures Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Linda L. Jagodzinski
5Diagnostics Countermeasures Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Dominic Paquin-Proulx
1U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Gregory D. Gromowski
6Virus Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Isabella Swafford
1U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Akshaya Ganesh
1U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
7Oak Ridge Institute of Science and Education, Oak Ridge, Tennessee USA
Ming Dong
1U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Xiankun Zeng
8Pathology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland USA
Paul V. Thomas
3Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Rajeshwer S. Sankhala
3Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Agnes Hajduczki
3Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Caroline E. Peterson
3Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Caitlin Kuklis
6Virus Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Sandrine Soman
6Virus Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Lindsay Wieczorek
1U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Michelle Zemil
1U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Alexander Anderson
3Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
7Oak Ridge Institute of Science and Education, Oak Ridge, Tennessee USA
Janice Darden
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
5Diagnostics Countermeasures Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Heather Hernandez
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
5Diagnostics Countermeasures Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Hannah Grove
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
5Diagnostics Countermeasures Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Vincent Dussupt
1U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Holly Hack
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
5Diagnostics Countermeasures Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Rafael de la Barrera
9Pilot Bioproduction Facility, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Stasya Zarling
9Pilot Bioproduction Facility, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
James F. Wood
9Pilot Bioproduction Facility, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Jeffrey W. Froude
9Pilot Bioproduction Facility, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Matthew Gagne
10Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA
Amy R. Henry
10Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA
Elham Bayat Mokhtari
11Virus Persistence and Dynamics Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA
Prakriti Mudvari
11Virus Persistence and Dynamics Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA
Shelly J. Krebs
1U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Andrew S. Pekosz
12W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland USA
Jeffrey R. Currier
6Virus Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Swagata Kar
13BioQual, Inc., Rockville, Maryland USA
Maciel Porto
13BioQual, Inc., Rockville, Maryland USA
Adrienne Winn
13BioQual, Inc., Rockville, Maryland USA
Kamil Radzyminski
13BioQual, Inc., Rockville, Maryland USA
Mark G. Lewis
13BioQual, Inc., Rockville, Maryland USA
Sandhya Vasan
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Mehul Suthar
14Emory Vaccine Center, Department of Pediatrics, Emory School of Medicine, Atlanta, Georgia USA
Victoria R. Polonis
1U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Gary R. Matyas
1U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Eli A. Boritz
11Virus Persistence and Dynamics Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA
Daniel C. Douek
10Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA
Robert A. Seder
15Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA
Sharon P. Daye
16One Health Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Mangala Rao
1U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Sheila A. Peel
5Diagnostics Countermeasures Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
M. Gordon Joyce
3Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Diane L. Bolton
1U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA
Nelson L. Michael
17Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Kayvon Modjarrad
3Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland USA
Article usage
Posted June 16, 2021.
A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters
Kathryn McGuckin Wuertz, Erica K. Barkei, Wei-Hung Chen, Elizabeth J. Martinez, Ines Lakhal-Naouar, Linda L. Jagodzinski, Dominic Paquin-Proulx, Gregory D. Gromowski, Isabella Swafford, Akshaya Ganesh, Ming Dong, Xiankun Zeng, Paul V. Thomas, Rajeshwer S. Sankhala, Agnes Hajduczki, Caroline E. Peterson, Caitlin Kuklis, Sandrine Soman, Lindsay Wieczorek, Michelle Zemil, Alexander Anderson, Janice Darden, Heather Hernandez, Hannah Grove, Vincent Dussupt, Holly Hack, Rafael de la Barrera, Stasya Zarling, James F. Wood, Jeffrey W. Froude, Matthew Gagne, Amy R. Henry, Elham Bayat Mokhtari, Prakriti Mudvari, Shelly J. Krebs, Andrew S. Pekosz, Jeffrey R. Currier, Swagata Kar, Maciel Porto, Adrienne Winn, Kamil Radzyminski, Mark G. Lewis, Sandhya Vasan, Mehul Suthar, Victoria R. Polonis, Gary R. Matyas, Eli A. Boritz, Daniel C. Douek, Robert A. Seder, Sharon P. Daye, Mangala Rao, Sheila A. Peel, M. Gordon Joyce, Diane L. Bolton, Nelson L. Michael, Kayvon Modjarrad
bioRxiv 2021.06.16.448525; doi: https://doi.org/10.1101/2021.06.16.448525
A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters
Kathryn McGuckin Wuertz, Erica K. Barkei, Wei-Hung Chen, Elizabeth J. Martinez, Ines Lakhal-Naouar, Linda L. Jagodzinski, Dominic Paquin-Proulx, Gregory D. Gromowski, Isabella Swafford, Akshaya Ganesh, Ming Dong, Xiankun Zeng, Paul V. Thomas, Rajeshwer S. Sankhala, Agnes Hajduczki, Caroline E. Peterson, Caitlin Kuklis, Sandrine Soman, Lindsay Wieczorek, Michelle Zemil, Alexander Anderson, Janice Darden, Heather Hernandez, Hannah Grove, Vincent Dussupt, Holly Hack, Rafael de la Barrera, Stasya Zarling, James F. Wood, Jeffrey W. Froude, Matthew Gagne, Amy R. Henry, Elham Bayat Mokhtari, Prakriti Mudvari, Shelly J. Krebs, Andrew S. Pekosz, Jeffrey R. Currier, Swagata Kar, Maciel Porto, Adrienne Winn, Kamil Radzyminski, Mark G. Lewis, Sandhya Vasan, Mehul Suthar, Victoria R. Polonis, Gary R. Matyas, Eli A. Boritz, Daniel C. Douek, Robert A. Seder, Sharon P. Daye, Mangala Rao, Sheila A. Peel, M. Gordon Joyce, Diane L. Bolton, Nelson L. Michael, Kayvon Modjarrad
bioRxiv 2021.06.16.448525; doi: https://doi.org/10.1101/2021.06.16.448525
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