New Results
A CRISPRi/a platform in iPSC-derived microglia uncovers regulators of disease states
Nina M. Dräger, Sydney M. Sattler, Cindy Tzu-Ling Huang, Olivia M. Teter, Kun Leng, Sayed Hadi Hashemi, Jason Hong, Claire D. Clelland, Lihong Zhan, Lay Kodama, Andrew B. Singleton, Mike A. Nalls, Justin Ichida, Michael E. Ward, Faraz Faghri, Li Gan, View ORCID ProfileMartin Kampmann
doi: https://doi.org/10.1101/2021.06.16.448639
Nina M. Dräger
1Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA
Sydney M. Sattler
1Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA
Cindy Tzu-Ling Huang
2Gladstone Institute of Neurological Disease, San Francisco, CA, USA
Olivia M. Teter
1Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA
3UC Berkeley-UCSF Graduate Program in Bioengineering, University of California San Francisco, San Francisco, CA, USA
Kun Leng
1Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA
4Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA
5Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA
Sayed Hadi Hashemi
6Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA
Jason Hong
1Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA
Claire D. Clelland
2Gladstone Institute of Neurological Disease, San Francisco, CA, USA
7Department of Neurology, University of California, San Francisco, CA, 94158, USA
Lihong Zhan
2Gladstone Institute of Neurological Disease, San Francisco, CA, USA
Lay Kodama
2Gladstone Institute of Neurological Disease, San Francisco, CA, USA
5Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA
8Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA
Andrew B. Singleton
9Center for Alzheimer’s and Related Dementias, National Institutes of Health, Bethesda, MD, USA
10Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Mike A. Nalls
9Center for Alzheimer’s and Related Dementias, National Institutes of Health, Bethesda, MD, USA
10Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
11Data Tecnica International, LLC, Glen Echo, MD, USA
Justin Ichida
12Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
13Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC, Los Angeles, CA, USA
14Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Michael E. Ward
15National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Faraz Faghri
6Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA
9Center for Alzheimer’s and Related Dementias, National Institutes of Health, Bethesda, MD, USA
10Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
11Data Tecnica International, LLC, Glen Echo, MD, USA
Li Gan
2Gladstone Institute of Neurological Disease, San Francisco, CA, USA
7Department of Neurology, University of California, San Francisco, CA, 94158, USA
16Helen and Robert Appel Alzheimer’s Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA
Martin Kampmann
1Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA
17Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA
18Chan Zuckerberg Biohub, San Francisco, CA, USA
Posted June 16, 2021.
A CRISPRi/a platform in iPSC-derived microglia uncovers regulators of disease states
Nina M. Dräger, Sydney M. Sattler, Cindy Tzu-Ling Huang, Olivia M. Teter, Kun Leng, Sayed Hadi Hashemi, Jason Hong, Claire D. Clelland, Lihong Zhan, Lay Kodama, Andrew B. Singleton, Mike A. Nalls, Justin Ichida, Michael E. Ward, Faraz Faghri, Li Gan, Martin Kampmann
bioRxiv 2021.06.16.448639; doi: https://doi.org/10.1101/2021.06.16.448639
A CRISPRi/a platform in iPSC-derived microglia uncovers regulators of disease states
Nina M. Dräger, Sydney M. Sattler, Cindy Tzu-Ling Huang, Olivia M. Teter, Kun Leng, Sayed Hadi Hashemi, Jason Hong, Claire D. Clelland, Lihong Zhan, Lay Kodama, Andrew B. Singleton, Mike A. Nalls, Justin Ichida, Michael E. Ward, Faraz Faghri, Li Gan, Martin Kampmann
bioRxiv 2021.06.16.448639; doi: https://doi.org/10.1101/2021.06.16.448639
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