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Developmental plasticity in visual cortex is necessary for normal visuomotor integration and visuomotor skill learning

View ORCID ProfileFelix C. Widmer, View ORCID ProfileGeorg B. Keller
doi: https://doi.org/10.1101/2021.06.20.449148
Felix C. Widmer
1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2Faculty of Natural Sciences, University of Basel, Basel, Switzerland
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  • ORCID record for Felix C. Widmer
Georg B. Keller
1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2Faculty of Natural Sciences, University of Basel, Basel, Switzerland
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  • For correspondence: georg.keller@fmi.ch
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SUMMARY

The experience of coupling between motor output and visual feedback is necessary for the development of visuomotor skills and shapes visuomotor integration in visual cortex. Whether these experience-dependent changes involve plasticity in visual cortex remains unclear. Here, we probed the role of NMDA receptor-dependent plasticity in mouse primary visual cortex (V1) during visuomotor development. Using a conditional knockout of NMDA receptors and a photoactivatable inhibitor of CaMKII, we locally perturbed plasticity in V1 during first visual experience, recorded neuronal activity in V1, and tested the mice in a visuomotor task. We found that perturbing plasticity before, but not after, first visuomotor experience reduces responses to unpredictable stimuli, diminishes the suppression of predictable feedback in V1, and impairs visuomotor skill learning later in life. Our results demonstrate that plasticity in the local V1 circuit during early life is critical for shaping visuomotor integration.

*** Dear reader, please note this manuscript is formatted in a standard submission format, and all statistical information is provided in Table S1. ***

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵3 Lead contact: georg.keller{at}fmi.ch

  • ABBREVIATIONS

    CaMKII
    Calcium/calmodulin-dependent protein kinase II
    Grin1
    Glutamate receptor ionotropic NMDA subunit 1
    L2/3
    Layer 2/3 of cortex
    L4
    Layer 4 of cortex
    L5
    Layer 5 of cortex
    NMDA
    N-Methyl-D-aspartate
    paAIP2
    photoactivatable autocamtide inhibitory peptide 2 (an inhibitor of CaMKII)
    PV
    Parvalbumin
    SEM
    Standard error of the mean
    SST
    Somatostatin
    V1
    Primary visual cortex
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    Posted June 20, 2021.
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    Developmental plasticity in visual cortex is necessary for normal visuomotor integration and visuomotor skill learning
    Felix C. Widmer, Georg B. Keller
    bioRxiv 2021.06.20.449148; doi: https://doi.org/10.1101/2021.06.20.449148
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    Developmental plasticity in visual cortex is necessary for normal visuomotor integration and visuomotor skill learning
    Felix C. Widmer, Georg B. Keller
    bioRxiv 2021.06.20.449148; doi: https://doi.org/10.1101/2021.06.20.449148

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