Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

The Digital Brain Bank, an open access platform for post-mortem datasets

View ORCID ProfileBenjamin C. Tendler, Taylor Hanayik, Olaf Ansorge, Sarah Bangerter-Christensen, Gregory S. Berns, Mads F. Bertelsen, Katherine L. Bryant, Sean Foxley, Martijn P. van den Heuvel, Amy F.D. Howard, Istvan Huszar, Alexandre A. Khrapitchev, Anna Leonte, Paul R. Manger, Ricarda A.L. Menke, Jeroen Mollink, Duncan Mortimer, Menuka Pallebage-Gamarallage, Lea Roumazeilles, Jerome Sallet, Lianne H. Scholtens, Connor Scott, Adele Smart, Martin R. Turner, Chaoyue Wang, Saad Jbabdi, Rogier B. Mars, Karla L. Miller
doi: https://doi.org/10.1101/2021.06.21.449154
Benjamin C. Tendler
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Benjamin C. Tendler
  • For correspondence: benjamin.tendler@ndcn.ox.ac.uk
Taylor Hanayik
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Olaf Ansorge
2Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sarah Bangerter-Christensen
2Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gregory S. Berns
3Psychology Department, Emory University, Atlanta, Georgia, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mads F. Bertelsen
4Centre for Zoo and Wild Animal Health, Copenhagen Zoo, Frederiksberg, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katherine L. Bryant
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sean Foxley
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
5Department of Radiology, University of Chicago, Chicago, Illinois, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martijn P. van den Heuvel
6Department of Complex Trait Genetics, Centre for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
7Department of Child Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amy F.D. Howard
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Istvan Huszar
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexandre A. Khrapitchev
8Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anna Leonte
2Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul R. Manger
9School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ricarda A.L. Menke
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeroen Mollink
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Duncan Mortimer
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Menuka Pallebage-Gamarallage
2Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lea Roumazeilles
10Wellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jerome Sallet
10Wellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
11Stem Cell and Brain Research Institute, Université Lyon 1, INSERM, Bron, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lianne H. Scholtens
6Department of Complex Trait Genetics, Centre for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Connor Scott
2Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Adele Smart
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
2Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martin R. Turner
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
2Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chaoyue Wang
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Saad Jbabdi
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rogier B. Mars
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
12Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Karla L. Miller
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Data/Code
  • Preview PDF
Loading

Abstract

Post-mortem MRI provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy, and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank), an interactive data discovery and release platform providing open access to curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes - Digital Neuroanatomist: datasets for detailed neuroanatomical investigations; Digital Brain Zoo: datasets for comparative neuroanatomy; Digital Pathologist: datasets for neuropathology investigations. The first Digital Brain Bank release includes twenty one distinctive whole-brain diffusion MRI datasets for structural connectivity investigations, alongside microscopy and complementary MRI modalities. This includes one of the highest-resolution whole-brain human diffusion MRI datasets ever acquired, whole-brain diffusion MRI in fourteen non-human primate species, and one of the largest post-mortem whole-brain cohort imaging studies in neurodegeneration. Taken together, the Digital Brain Bank provides a cross-scale, cross-species investigation framework facilitating the incorporation of post-mortem data into neuroimaging studies.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://open.win.ox.ac.uk/DigitalBrainBank

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Back to top
PreviousNext
Posted September 01, 2021.
Download PDF

Supplementary Material

Data/Code
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
The Digital Brain Bank, an open access platform for post-mortem datasets
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
The Digital Brain Bank, an open access platform for post-mortem datasets
Benjamin C. Tendler, Taylor Hanayik, Olaf Ansorge, Sarah Bangerter-Christensen, Gregory S. Berns, Mads F. Bertelsen, Katherine L. Bryant, Sean Foxley, Martijn P. van den Heuvel, Amy F.D. Howard, Istvan Huszar, Alexandre A. Khrapitchev, Anna Leonte, Paul R. Manger, Ricarda A.L. Menke, Jeroen Mollink, Duncan Mortimer, Menuka Pallebage-Gamarallage, Lea Roumazeilles, Jerome Sallet, Lianne H. Scholtens, Connor Scott, Adele Smart, Martin R. Turner, Chaoyue Wang, Saad Jbabdi, Rogier B. Mars, Karla L. Miller
bioRxiv 2021.06.21.449154; doi: https://doi.org/10.1101/2021.06.21.449154
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
The Digital Brain Bank, an open access platform for post-mortem datasets
Benjamin C. Tendler, Taylor Hanayik, Olaf Ansorge, Sarah Bangerter-Christensen, Gregory S. Berns, Mads F. Bertelsen, Katherine L. Bryant, Sean Foxley, Martijn P. van den Heuvel, Amy F.D. Howard, Istvan Huszar, Alexandre A. Khrapitchev, Anna Leonte, Paul R. Manger, Ricarda A.L. Menke, Jeroen Mollink, Duncan Mortimer, Menuka Pallebage-Gamarallage, Lea Roumazeilles, Jerome Sallet, Lianne H. Scholtens, Connor Scott, Adele Smart, Martin R. Turner, Chaoyue Wang, Saad Jbabdi, Rogier B. Mars, Karla L. Miller
bioRxiv 2021.06.21.449154; doi: https://doi.org/10.1101/2021.06.21.449154

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4235)
  • Biochemistry (9136)
  • Bioengineering (6784)
  • Bioinformatics (24001)
  • Biophysics (12129)
  • Cancer Biology (9534)
  • Cell Biology (13778)
  • Clinical Trials (138)
  • Developmental Biology (7636)
  • Ecology (11702)
  • Epidemiology (2066)
  • Evolutionary Biology (15513)
  • Genetics (10644)
  • Genomics (14326)
  • Immunology (9483)
  • Microbiology (22840)
  • Molecular Biology (9090)
  • Neuroscience (48995)
  • Paleontology (355)
  • Pathology (1482)
  • Pharmacology and Toxicology (2570)
  • Physiology (3846)
  • Plant Biology (8331)
  • Scientific Communication and Education (1471)
  • Synthetic Biology (2296)
  • Systems Biology (6192)
  • Zoology (1301)