ABSTRACT
We analyzed peripheral blood mononuclear cells (PBMCs) of each 20 individuals with a high anti-SARS-CoV-2 antibody titer and a low antibody titer out of 1,774 healthcare workers who received BNT162b2 mRNA vaccine. A higher antibody titer was associated with the frequencies of naïve and transitional B cells before vaccination. In addition, fold changes in the frequency of activated CD8+ T cells upon vaccination were correlated with the antibody titers.
Competing Interest Statement
The authors have declared no competing interest.
Copyright
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Posted June 21, 2021.
Immunological features that determine the strength of antibody responses to BNT162b2 mRNA vaccine against SARS-CoV-2
