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Tau assemblies enter the cytosol in a cholesterol sensitive process essential to seeded aggregation

View ORCID ProfileBenjamin J. Tuck, View ORCID ProfileLauren V. C. Miller, View ORCID ProfileEmma L. Wilson, View ORCID ProfileTaxiarchis Katsinelos, View ORCID ProfileShi Cheng, Marina Vaysburd, Claire Knox, Lucy Tredgett, Emmanouil Metzakopian, Leo C. James, View ORCID ProfileWilliam A. McEwan
doi: https://doi.org/10.1101/2021.06.21.449238
Benjamin J. Tuck
1UK Dementia Research Institute at the University of Cambridge, Department of Clinical Neurosciences, Hill Road, Cambridge, CB2 0AH
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  • ORCID record for Benjamin J. Tuck
  • For correspondence: bjt44@cam.ac.uk wm305@cam.ac.uk
Lauren V. C. Miller
1UK Dementia Research Institute at the University of Cambridge, Department of Clinical Neurosciences, Hill Road, Cambridge, CB2 0AH
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  • ORCID record for Lauren V. C. Miller
Emma L. Wilson
1UK Dementia Research Institute at the University of Cambridge, Department of Clinical Neurosciences, Hill Road, Cambridge, CB2 0AH
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  • ORCID record for Emma L. Wilson
Taxiarchis Katsinelos
1UK Dementia Research Institute at the University of Cambridge, Department of Clinical Neurosciences, Hill Road, Cambridge, CB2 0AH
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  • ORCID record for Taxiarchis Katsinelos
Shi Cheng
1UK Dementia Research Institute at the University of Cambridge, Department of Clinical Neurosciences, Hill Road, Cambridge, CB2 0AH
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Marina Vaysburd
2MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH
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Claire Knox
2MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH
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Lucy Tredgett
2MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH
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Emmanouil Metzakopian
1UK Dementia Research Institute at the University of Cambridge, Department of Clinical Neurosciences, Hill Road, Cambridge, CB2 0AH
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Leo C. James
2MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH
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William A. McEwan
1UK Dementia Research Institute at the University of Cambridge, Department of Clinical Neurosciences, Hill Road, Cambridge, CB2 0AH
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  • ORCID record for William A. McEwan
  • For correspondence: bjt44@cam.ac.uk wm305@cam.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2021.06.21.449238
History 
  • September 15, 2021.

Article Versions

  • Version 1 (June 22, 2021 - 11:55).
  • Version 2 (June 28, 2021 - 21:55).
  • You are viewing Version 3, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Benjamin J. Tuck1,*,
  2. Lauren V. C. Miller1,
  3. Emma L. Wilson1,
  4. Taxiarchis Katsinelos1,
  5. Shi Cheng1,
  6. Marina Vaysburd2,
  7. Claire Knox2,
  8. Lucy Tredgett2,
  9. Emmanouil Metzakopian1,
  10. Leo C. James2 and
  11. William A. McEwan1,*
  1. 1UK Dementia Research Institute at the University of Cambridge, Department of Clinical Neurosciences, Hill Road, Cambridge, CB2 0AH
  2. 2MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH
  1. ↵*Correspondence: bjt44{at}cam.ac.uk, wm305{at}cam.ac.uk
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Posted September 15, 2021.
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Tau assemblies enter the cytosol in a cholesterol sensitive process essential to seeded aggregation
Benjamin J. Tuck, Lauren V. C. Miller, Emma L. Wilson, Taxiarchis Katsinelos, Shi Cheng, Marina Vaysburd, Claire Knox, Lucy Tredgett, Emmanouil Metzakopian, Leo C. James, William A. McEwan
bioRxiv 2021.06.21.449238; doi: https://doi.org/10.1101/2021.06.21.449238
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Tau assemblies enter the cytosol in a cholesterol sensitive process essential to seeded aggregation
Benjamin J. Tuck, Lauren V. C. Miller, Emma L. Wilson, Taxiarchis Katsinelos, Shi Cheng, Marina Vaysburd, Claire Knox, Lucy Tredgett, Emmanouil Metzakopian, Leo C. James, William A. McEwan
bioRxiv 2021.06.21.449238; doi: https://doi.org/10.1101/2021.06.21.449238

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