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A binocular synaptic network supports interocular response alignment in visual cortical neurons

View ORCID ProfileBenjamin Scholl, View ORCID ProfileClara Tepohl, Melissa A. Ryan, View ORCID ProfileConnon I. Thomas, Naomi Kamasawa, View ORCID ProfileDavid Fitzpatrick
doi: https://doi.org/10.1101/2021.06.22.449272
Benjamin Scholl
3Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
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  • For correspondence: Benjamin.Scholl@pennmedicine.upenn.edu
Clara Tepohl
1Functional Architecture and Development of Cerebral Cortex, Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL, USA
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Melissa A. Ryan
2Electron Microscopy Core Facility, Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL, USA
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Connon I. Thomas
2Electron Microscopy Core Facility, Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL, USA
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Naomi Kamasawa
2Electron Microscopy Core Facility, Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL, USA
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David Fitzpatrick
1Functional Architecture and Development of Cerebral Cortex, Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL, USA
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Abstract

In the visual system, signals from the two eyes are combined to form a coherent representation through the convergence of synaptic input populations onto individual cortical neurons. As individual synapses originate from either monocular (representing one eye) or binocular (representing both eyes) cortical networks, it has been unclear how these inputs are integrated coherently. Here, we imaged dendritic spines on layer 2/3 binocular cells in ferret visual cortex with in vivo two-photon microscopy to examine how monocular and binocular synaptic networks contribute to the interocular alignment of orientation tuning. We found that binocular synapses varied in degree of ‘congruency’, namely response correlation between left and right eye visual stimulation. Binocular congruent inputs were functionally distinct from binocular noncongruent and monocular inputs, exhibiting greater tuning selectivity and connection specificity. Using correlative light and electron microscopy, we found no difference in ultrastructural anatomy and instead, observed strength in numbers using a simple model simulating aggregate synaptic input. This model demonstrated a predominate contribution of binocular congruent inputs in sculpting somatic orientation preference and interocular response alignment. Our study suggests that, in layer 2/3 cortical neurons, a binocular network is responsible for forming a coherent representation in individual neurons through recurrent intracortical interactions.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted June 22, 2021.
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A binocular synaptic network supports interocular response alignment in visual cortical neurons
Benjamin Scholl, Clara Tepohl, Melissa A. Ryan, Connon I. Thomas, Naomi Kamasawa, David Fitzpatrick
bioRxiv 2021.06.22.449272; doi: https://doi.org/10.1101/2021.06.22.449272
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A binocular synaptic network supports interocular response alignment in visual cortical neurons
Benjamin Scholl, Clara Tepohl, Melissa A. Ryan, Connon I. Thomas, Naomi Kamasawa, David Fitzpatrick
bioRxiv 2021.06.22.449272; doi: https://doi.org/10.1101/2021.06.22.449272

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