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Coordination games in cancer

Péter Bayer, Robert A. Gatenby, Patricia H. McDonald, Derek R. Duckett, Kateřina Staňková, Joel S. Brown
doi: https://doi.org/10.1101/2021.06.22.449436
Péter Bayer
†Toulouse School of Economics and Institute for Advance Study in Toulouse, 1 Espalade de l’Université, 31080 Toulouse, France. E-mail:
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  • For correspondence: peter.bayer@tse-fr.eu
Robert A. Gatenby
‡Department of Integrated Mathematical Oncology, Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, United States. E-mail:
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  • For correspondence: Robert.Gatenby@moffitt.org
Patricia H. McDonald
§Department of Cancer Physiology, Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, United States. E-mail:
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  • For correspondence: Patsy.McDonald@moffitt.org
Derek R. Duckett
¶Department of Drug Discovery, Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, United States. E-mail:
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  • For correspondence: Derek.Duckett@moffitt.org
Kateřina Staňková
‖Department of Data Science & Knowledge Engineering, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands and Delft Institute of Applied Mathematics, Delft University, Mekelweg 4, 2628 CD Delft, The Netherlands. E-mail:
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  • For correspondence: k.stankova@maastrichtuniversity.nl
Joel S. Brown
**Department of Integrated Mathematical Oncology, Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, United States. E-mail:
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  • For correspondence: Joel.Brown@moffitt.org
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Abstract

We propose a model of cancer initiation and progression where tumor growth is modulated by an evolutionary coordination game. Evolutionary games of cancer are widely used to model frequency-dependent cell interactions with the most studied games being the Prisoner’s Dilemma and public goods games. Coordination games, by their more obscure and less evocative nature, are left understudied, despite the fact that, as we argue, they offer great potential in understanding and treating cancer. In this paper we present the conditions under which coordination games between cancer cells evolve, we propose aspects of cancer that can be modeled as results of coordination games, and explore the ways through which coordination games of cancer can be exploited for therapy.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • * We thank Ingela Alger, Dave Basanta, Monica Salvioli, and Jeffrey West, as well as seminar participants of Moffitt’s Integrated Mathematical Oncology Department and the Institute of Advance Studies in Toulouse for useful discussions and comments

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted June 24, 2021.
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Coordination games in cancer
Péter Bayer, Robert A. Gatenby, Patricia H. McDonald, Derek R. Duckett, Kateřina Staňková, Joel S. Brown
bioRxiv 2021.06.22.449436; doi: https://doi.org/10.1101/2021.06.22.449436
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Coordination games in cancer
Péter Bayer, Robert A. Gatenby, Patricia H. McDonald, Derek R. Duckett, Kateřina Staňková, Joel S. Brown
bioRxiv 2021.06.22.449436; doi: https://doi.org/10.1101/2021.06.22.449436

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