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Modules in connectomes of phase-synchronization comprise anatomically contiguous, functionally related regions

View ORCID ProfileN Williams, SH Wang, G Arnulfo, L Nobili, S Palva, JM Palva
doi: https://doi.org/10.1101/2021.06.24.449415
N Williams
1Department of Neuroscience & Biomedical Engineering, Aalto University, Espoo, Finland
2BioMag laboratory, HUS Medical Imaging Centre, Helsinki, Finland
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  • ORCID record for N Williams
  • For correspondence: nitin.williams@aalto.fi
SH Wang
1Department of Neuroscience & Biomedical Engineering, Aalto University, Espoo, Finland
3Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Finland
4INRIA (National Institute for Research in Digital Science & Technology) Saclay, MIND team, Université Paris-Saclay, Paris, France
5CEA (French Alternative Energies and Atomic Energy Commission)/ Neurospin, Paris, France
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G Arnulfo
3Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Finland
6Dept. of Informatics, Bioengineering, Robotics & Systems Engineering, University of Genoa, Genoa, Italy
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L Nobili
7Claudio Munari Epilepsy Surgery Centre, Niguarda Hospital, Milan, Italy
8Department of Neurosciences, Rehabilitation, Ophthamology, Genetics and Maternal and Children’s Sciences, University of Genoa, Genoa, Italy
9Child Neuropsychiatry, IRCCs Gaslini Istituto Giannina Gaslini, Genoa, Italy
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S Palva
2BioMag laboratory, HUS Medical Imaging Centre, Helsinki, Finland
3Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Finland
10Centre for Cognitive Neuroimaging, Institute of Neuroscience & Psychology, University of Glasgow, Glasgow, United Kingdom
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JM Palva
1Department of Neuroscience & Biomedical Engineering, Aalto University, Espoo, Finland
3Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Finland
10Centre for Cognitive Neuroimaging, Institute of Neuroscience & Psychology, University of Glasgow, Glasgow, United Kingdom
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Abstract

Modules in brain functional connectomes are essential to balancing segregation and integration of neuronal activity. Connectomes are the complete set of pairwise connections between brain regions. Non-invasive Electroencephalography (EEG) and Magnetoencephalography (MEG) have been used to identify modules in connectomes of phase-synchronization. However, their resolution is suboptimal because of spurious phase-synchronization due to EEG volume conduction or MEG field spread. Here, we used invasive, intracerebral recordings from stereo-electroencephalography (SEEG, N = 67), to identify modules in connectomes of phase-synchronization. To generate SEEG-based group-level connectomes affected only minimally by volume conduction, we used submillimeter accurate localization of SEEG contacts and referenced electrode contacts in cortical grey matter to their closest contacts in white matter. Combining community detection methods with consensus clustering, we found that the connectomes of phase-synchronization were characterized by distinct and stable modules at multiple spatial scales, across frequencies from 3 to 320 Hz. These modules were highly similar within canonical frequency bands. Unlike the distributed brain systems identified with functional Magnetic Resonance Imaging (fMRI), modules up to the high-gamma frequency band comprised only anatomically contiguous regions. Notably, the identified modules comprised cortical regions involved in shared repertoires of sensorimotor and cognitive functions including memory, language and attention. These results suggest that the identified modules represent functionally specialised brain systems, which only partially overlap with the brain systems reported with fMRI. Hence, these modules might regulate the balance between functional segregation and functional integration through phase-synchronization.

Highlights

  • Large-cohort SEEG used for phase-synchronization connectomics

  • Connectomes of phase-synchronization possess distinct and stable modules

  • Modules in connectomes are highly similar within canonical frequency bands

  • Modules in connectomes comprise anatomically contiguous regions

  • Modules in connectomes comprise functionally related regions

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • added Figure 4 and Figure 4 caption

  • https://data.mendeley.com/datasets/ypx74nmfs8/2

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 22, 2023.
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Modules in connectomes of phase-synchronization comprise anatomically contiguous, functionally related regions
N Williams, SH Wang, G Arnulfo, L Nobili, S Palva, JM Palva
bioRxiv 2021.06.24.449415; doi: https://doi.org/10.1101/2021.06.24.449415
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Modules in connectomes of phase-synchronization comprise anatomically contiguous, functionally related regions
N Williams, SH Wang, G Arnulfo, L Nobili, S Palva, JM Palva
bioRxiv 2021.06.24.449415; doi: https://doi.org/10.1101/2021.06.24.449415

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