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Sensory and choice responses in MT distinct from motion encoding

View ORCID ProfileAaron J Levi, View ORCID ProfileYuan Zhao, View ORCID ProfileIl Memming Park, View ORCID ProfileAlexander C Huk
doi: https://doi.org/10.1101/2021.06.24.449836
Aaron J Levi
1Center for Perceptual Systems, Departments of Neuroscience & Psychology, The University of Texas at Austin, Austin, Texas, United States of America
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Yuan Zhao
2Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York, United States of America
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Il Memming Park
2Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York, United States of America
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Alexander C Huk
1Center for Perceptual Systems, Departments of Neuroscience & Psychology, The University of Texas at Austin, Austin, Texas, United States of America
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  • For correspondence: huk@utexas.edu
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Abstract

Macaque area MT is well known for its visual motion selectivity and relevance to motion perception, but the possibility of it also reflecting non-sensory functions has largely been ignored. Manipulating subjects’ temporal evidence weighting revealed multiple components of MT responses that were, surprisingly, not interpretable as behaviorally-relevant modulations of motion encoding, nor as consequences of readout of motion direction. MT’s time-varying motion-driven responses were starkly changed by our strategic manipulation, but with timecourses opposite the subjects’ temporal weighting strategies. Furthermore, large choice-correlated signals were represented in population activity distinctly from motion responses (even after the stimulus) with multiple phases that both lagged psychophysical readout and preceded motor responses. These results reveal multiple cognitive contributions to MT responses that are task-related but not functionally relevant to encoding or decoding of motion for psychophysical direction discrimination, calling into question its nature as a simple sensory area.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted June 25, 2021.
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Sensory and choice responses in MT distinct from motion encoding
Aaron J Levi, Yuan Zhao, Il Memming Park, Alexander C Huk
bioRxiv 2021.06.24.449836; doi: https://doi.org/10.1101/2021.06.24.449836
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Sensory and choice responses in MT distinct from motion encoding
Aaron J Levi, Yuan Zhao, Il Memming Park, Alexander C Huk
bioRxiv 2021.06.24.449836; doi: https://doi.org/10.1101/2021.06.24.449836

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