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Bacterial filamentation is an in vivo mechanism for cell-to-cell spreading

Tuan D Tran, Munira Aman Ali, Davin Lee, Marie-Anne Félix, View ORCID ProfileRobert J Luallen
doi: https://doi.org/10.1101/2021.06.27.450094
Tuan D Tran
1Department of Biology, San Diego State University, San Diego, CA 92182, USA
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Munira Aman Ali
1Department of Biology, San Diego State University, San Diego, CA 92182, USA
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Davin Lee
1Department of Biology, San Diego State University, San Diego, CA 92182, USA
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Marie-Anne Félix
2Institut de Biologie de l’ École Normale Supérieure, Centre National de la Recherche Scientifique, INSERM, École Normale Supérieure, Paris Sciences et Lettres, Paris, France
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Robert J Luallen
1Department of Biology, San Diego State University, San Diego, CA 92182, USA
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  • ORCID record for Robert J Luallen
  • For correspondence: rluallen@sdsu.edu
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ABSTRACT

Intracellular pathogens are challenged with limited space and resources while replicating in a single host cell. Mechanisms for direct invasion of neighboring host cells have been discovered in cell culture, but we lack an understanding of how bacteria directly spread from cell-to-cell in vivo. Here, we describe the discovery of a bacterial species that uses filamentation as an in vivo mechanism for intracellular spreading between the intestinal epithelial cells of its host, the rhabditid nematode Oscheius tipulae. In vitro and in vivo filamentation by this bacterium, Bordetella atropi, requires a highly conserved nutrient-sensing pathway used by divergent bacteria to detect rich conditions and inhibit the divisome. Thus, B. atropi uses a distinct mechanism for cell-to-cell spreading by coopting a pathway that normally regulates bacterial cell size to trigger filamentation inside host cells.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted November 21, 2021.
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Bacterial filamentation is an in vivo mechanism for cell-to-cell spreading
Tuan D Tran, Munira Aman Ali, Davin Lee, Marie-Anne Félix, Robert J Luallen
bioRxiv 2021.06.27.450094; doi: https://doi.org/10.1101/2021.06.27.450094
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Bacterial filamentation is an in vivo mechanism for cell-to-cell spreading
Tuan D Tran, Munira Aman Ali, Davin Lee, Marie-Anne Félix, Robert J Luallen
bioRxiv 2021.06.27.450094; doi: https://doi.org/10.1101/2021.06.27.450094

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