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Intrinsic Network Activity Reflects the Fluctuating Experience of Tonic Pain

Bettina Deak, Thomas Eggert, Astrid Mayr, View ORCID ProfileAnne Stankewitz, Filipp Filippopulos, Pauline Jahn, Viktor Witkovsky, Andreas Straube, View ORCID ProfileEnrico Schulz
doi: https://doi.org/10.1101/2021.06.30.450591
Bettina Deak
1Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany
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  • For correspondence: bettina.i.deak@gmail.com es@pain.sc
Thomas Eggert
1Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany
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Astrid Mayr
1Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany
3Department of Radiology, Ludwig-Maximilians-Universität München, Munich, Germany
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Anne Stankewitz
1Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany
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  • ORCID record for Anne Stankewitz
Filipp Filippopulos
1Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany
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Pauline Jahn
1Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany
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Viktor Witkovsky
4Department of Theoretical Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovak Republic
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Andreas Straube
1Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany
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Enrico Schulz
1Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany
2Department of Medical Psychology, Ludwig-Maximilians-Universität München, Munich, Germany
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  • ORCID record for Enrico Schulz
  • For correspondence: bettina.i.deak@gmail.com es@pain.sc
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Abstract

Although we know sensation is continuous, research on long-lasting and continuously changing stimuli is scarce and the dynamic nature of ongoing cortical processing is largely neglected.

In a longitudinal study with 152 fMRI sessions, participants were asked to continuously rate the intensity of applied tonic heat pain for 20 minutes. Using group independent component analysis and dual-regression, we extracted the subjects’ time courses of intrinsic network activity. The relationship between the dynamic fluctuation of network activity with the varying time courses of three pain processing entities was computed: pain intensity, the direction of pain intensity changes and temperature.

We were able to dissociate the spatio-temporal patterns of objective (temperature) and subjective (pain intensity/changes of pain intensity) aspects of pain processing in the human brain. We found two somatosensory networks with distinct functions: one network which encodes the small fluctuations in temperature and consists mainly of bilateral SI. A second right-lateralised network that encodes the intensity of the subjective experience of pain consists of SI, SII, the PCC, and the thalamus.

We revealed the somatosensory dynamics that build up towards a current subjective percept of pain. The timing suggests a cascade of subsequent processing steps towards the current pain percept.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Figures were swapped.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted July 07, 2021.
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Intrinsic Network Activity Reflects the Fluctuating Experience of Tonic Pain
Bettina Deak, Thomas Eggert, Astrid Mayr, Anne Stankewitz, Filipp Filippopulos, Pauline Jahn, Viktor Witkovsky, Andreas Straube, Enrico Schulz
bioRxiv 2021.06.30.450591; doi: https://doi.org/10.1101/2021.06.30.450591
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Intrinsic Network Activity Reflects the Fluctuating Experience of Tonic Pain
Bettina Deak, Thomas Eggert, Astrid Mayr, Anne Stankewitz, Filipp Filippopulos, Pauline Jahn, Viktor Witkovsky, Andreas Straube, Enrico Schulz
bioRxiv 2021.06.30.450591; doi: https://doi.org/10.1101/2021.06.30.450591

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