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Spike protein cleavage-activation mediated by the SARS-CoV-2 P681R mutation: a case-study from its first appearance in variant of interest (VOI) A.23.1 identified in Uganda
Bailey Lubinski, Laura E. Frazier, My V.T. Phan, Daniel L. Bugembe, Tiffany Tang, Susan Daniel, View ORCID ProfileMatthew Cotten, View ORCID ProfileJavier A. Jaimes, Gary R. Whittaker
doi: https://doi.org/10.1101/2021.06.30.450632
Bailey Lubinski
1Graduate Program in Biological & Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA
2Department of Microbiology & Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA
Laura E. Frazier
1Graduate Program in Biological & Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA
2Department of Microbiology & Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA
My V.T. Phan
3MRC/UVRI & London School of Hygiene and Tropical Medicine – Uganda Research Unit, Entebbe, Uganda
Daniel L. Bugembe
3MRC/UVRI & London School of Hygiene and Tropical Medicine – Uganda Research Unit, Entebbe, Uganda
Tiffany Tang
4Robert Frederick Smith School of Chemical & Biomolecular Engineering, Cornell University, Ithaca, NY, 14853, USA
Susan Daniel
4Robert Frederick Smith School of Chemical & Biomolecular Engineering, Cornell University, Ithaca, NY, 14853, USA
Matthew Cotten
3MRC/UVRI & London School of Hygiene and Tropical Medicine – Uganda Research Unit, Entebbe, Uganda
5MRC Centre of Virus Research, University of Glasgow, Glasgow, United Kingdom
Javier A. Jaimes
2Department of Microbiology & Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA
Gary R. Whittaker
2Department of Microbiology & Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA
6Master of Public Health Program, Cornell University, Ithaca, NY, 14853, USA

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Posted July 27, 2021.
Spike protein cleavage-activation mediated by the SARS-CoV-2 P681R mutation: a case-study from its first appearance in variant of interest (VOI) A.23.1 identified in Uganda
Bailey Lubinski, Laura E. Frazier, My V.T. Phan, Daniel L. Bugembe, Tiffany Tang, Susan Daniel, Matthew Cotten, Javier A. Jaimes, Gary R. Whittaker
bioRxiv 2021.06.30.450632; doi: https://doi.org/10.1101/2021.06.30.450632
Spike protein cleavage-activation mediated by the SARS-CoV-2 P681R mutation: a case-study from its first appearance in variant of interest (VOI) A.23.1 identified in Uganda
Bailey Lubinski, Laura E. Frazier, My V.T. Phan, Daniel L. Bugembe, Tiffany Tang, Susan Daniel, Matthew Cotten, Javier A. Jaimes, Gary R. Whittaker
bioRxiv 2021.06.30.450632; doi: https://doi.org/10.1101/2021.06.30.450632
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