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CRISPRa screening with real world evidence identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2
Chengkun Wang, Ravi K. Dinesh, Yuanhao Qu, View ORCID ProfileArjun Rustagi, Henry Cousins, James Zengel, Yinglong Guo, Taryn Hall, Aimee Beck, Luke Tso, Elif Tokar Erdemic, Kae Tanudtanud, Sheng Ren, Kathy Tzy-Hwa Tzeng, Aaron Wilk, Mengdi Wang, Jan Carette, View ORCID ProfileRuss Altman, Catherine A. Blish, View ORCID ProfileLe Cong
doi: https://doi.org/10.1101/2021.07.01.450475
Chengkun Wang
1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
Ravi K. Dinesh
1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
Yuanhao Qu
1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
2Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
3Cancer Biology Program, Stanford University School of Medicine, Stanford, CA, USA
Arjun Rustagi
4Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
Henry Cousins
1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
5Medical Scientist Training Program, Stanford University School of Medicine, Stanford, CA, USA
James Zengel
6Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA
Yinglong Guo
7Research and Development at UnitedHealth Group, Minneapolis, MN, USA
Taryn Hall
7Research and Development at UnitedHealth Group, Minneapolis, MN, USA
Aimee Beck
4Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
Luke Tso
7Research and Development at UnitedHealth Group, Minneapolis, MN, USA
Elif Tokar Erdemic
7Research and Development at UnitedHealth Group, Minneapolis, MN, USA
Kae Tanudtanud
7Research and Development at UnitedHealth Group, Minneapolis, MN, USA
Sheng Ren
7Research and Development at UnitedHealth Group, Minneapolis, MN, USA
Kathy Tzy-Hwa Tzeng
7Research and Development at UnitedHealth Group, Minneapolis, MN, USA
Aaron Wilk
4Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
5Medical Scientist Training Program, Stanford University School of Medicine, Stanford, CA, USA
Mengdi Wang
8Center for Statistics and Machine Learning, Department of Electrical and Computer Engineering, Princeton University, Princeton, NJ, USA
Jan Carette
2Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
6Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA
Russ Altman
2Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
4Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
9Department of Bioengineering, Stanford University, Stanford, CA, USA
Catherine A. Blish
4Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
5Medical Scientist Training Program, Stanford University School of Medicine, Stanford, CA, USA
10Chan Zuckerberg Biohub, San Francisco, CA, USA
Le Cong
1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
2Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
3Cancer Biology Program, Stanford University School of Medicine, Stanford, CA, USA
Posted July 01, 2021.
CRISPRa screening with real world evidence identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2
Chengkun Wang, Ravi K. Dinesh, Yuanhao Qu, Arjun Rustagi, Henry Cousins, James Zengel, Yinglong Guo, Taryn Hall, Aimee Beck, Luke Tso, Elif Tokar Erdemic, Kae Tanudtanud, Sheng Ren, Kathy Tzy-Hwa Tzeng, Aaron Wilk, Mengdi Wang, Jan Carette, Russ Altman, Catherine A. Blish, Le Cong
bioRxiv 2021.07.01.450475; doi: https://doi.org/10.1101/2021.07.01.450475
CRISPRa screening with real world evidence identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2
Chengkun Wang, Ravi K. Dinesh, Yuanhao Qu, Arjun Rustagi, Henry Cousins, James Zengel, Yinglong Guo, Taryn Hall, Aimee Beck, Luke Tso, Elif Tokar Erdemic, Kae Tanudtanud, Sheng Ren, Kathy Tzy-Hwa Tzeng, Aaron Wilk, Mengdi Wang, Jan Carette, Russ Altman, Catherine A. Blish, Le Cong
bioRxiv 2021.07.01.450475; doi: https://doi.org/10.1101/2021.07.01.450475
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