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Thiol-based mucolytics exhibit antiviral activity against SARS-CoV-2 through allosteric disulfide disruption in the spike glycoprotein
View ORCID ProfileYunlong Shi, Ari Zeida, Caitlin E. Edwards, Michael L. Mallory, Santiago Sastre, View ORCID ProfileMatías R. Machado, Raymond J. Pickles, Ling Fu, Keke Liu, Jing Yang, Ralph S. Baric, Richard C. Boucher, Rafael Radi, View ORCID ProfileKate S. Carroll
doi: https://doi.org/10.1101/2021.07.01.450701
Yunlong Shi
3Department of Chemistry, Scripps Research, Jupiter, Florida 33458, United States
Ari Zeida
2Departamento de Bioquímica, Facultad de Medicina and Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Montevideo 11800, Uruguay
Caitlin E. Edwards
6Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States
Michael L. Mallory
6Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States
Santiago Sastre
2Departamento de Bioquímica, Facultad de Medicina and Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Montevideo 11800, Uruguay
Matías R. Machado
9Institut Pasteur de Montevideo, Montevideo 11400, Uruguay
Raymond J. Pickles
1Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States
Ling Fu
11State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences • Beijing, Beijing Institute of Lifeomics, Beijing 102206, China
Keke Liu
11State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences • Beijing, Beijing Institute of Lifeomics, Beijing 102206, China
Jing Yang
11State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences • Beijing, Beijing Institute of Lifeomics, Beijing 102206, China
Ralph S. Baric
14Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States
Richard C. Boucher
1Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States
Rafael Radi
2Departamento de Bioquímica, Facultad de Medicina and Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Montevideo 11800, Uruguay
Kate S. Carroll
3Department of Chemistry, Scripps Research, Jupiter, Florida 33458, United States
Posted July 01, 2021.
Thiol-based mucolytics exhibit antiviral activity against SARS-CoV-2 through allosteric disulfide disruption in the spike glycoprotein
Yunlong Shi, Ari Zeida, Caitlin E. Edwards, Michael L. Mallory, Santiago Sastre, Matías R. Machado, Raymond J. Pickles, Ling Fu, Keke Liu, Jing Yang, Ralph S. Baric, Richard C. Boucher, Rafael Radi, Kate S. Carroll
bioRxiv 2021.07.01.450701; doi: https://doi.org/10.1101/2021.07.01.450701
Thiol-based mucolytics exhibit antiviral activity against SARS-CoV-2 through allosteric disulfide disruption in the spike glycoprotein
Yunlong Shi, Ari Zeida, Caitlin E. Edwards, Michael L. Mallory, Santiago Sastre, Matías R. Machado, Raymond J. Pickles, Ling Fu, Keke Liu, Jing Yang, Ralph S. Baric, Richard C. Boucher, Rafael Radi, Kate S. Carroll
bioRxiv 2021.07.01.450701; doi: https://doi.org/10.1101/2021.07.01.450701
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