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Ad26.COV2.S elicited neutralizing activity against Delta and other SARS-CoV-2 variants of concern

Mandy Jongeneelen, Krisztian Kaszas, Daniel Veldman, Jeroen Huizingh, Remko van der Vlugt, Theo Schouten, David Zuijdgeest, Taco Uil, Griet van Roey, Nuria Guimera, Marjon Navis, Rinke Bos, Mathieu le Gars, Jerald Sadoff, Leacky Muchene, Jarek Juraszek, Johannes PM Langedijk, Ronald Vogels, Jerome Custers, Hanneke Schuitemaker, View ORCID ProfileBoerries Brandenburg
doi: https://doi.org/10.1101/2021.07.01.450707
Mandy Jongeneelen
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Krisztian Kaszas
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Daniel Veldman
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Jeroen Huizingh
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Remko van der Vlugt
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Theo Schouten
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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David Zuijdgeest
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Taco Uil
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Griet van Roey
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Nuria Guimera
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Marjon Navis
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Rinke Bos
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Mathieu le Gars
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Jerald Sadoff
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Leacky Muchene
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Jarek Juraszek
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Johannes PM Langedijk
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Ronald Vogels
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Jerome Custers
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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Hanneke Schuitemaker
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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  • For correspondence: hschuite@its.jnj.com bbrande1@its.jnj.com
Boerries Brandenburg
1Janssen Vaccines & Prevention, Leiden, The Netherlands
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  • ORCID record for Boerries Brandenburg
  • For correspondence: hschuite@its.jnj.com bbrande1@its.jnj.com
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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve and recently emerging variants with substitutions in the Spike protein have led to growing concerns over increased transmissibility and decreased vaccine coverage due to immune evasion. Here, sera from recipients of a single dose of our Ad26.COV2.S COVID-19 vaccine were tested for neutralizing activity against several SARS-CoV-2 variants of concern. All tested variants demonstrated susceptibility to Ad26.COV2.S-induced serum neutralization albeit mainly reduced as compared to the B.1 strain. Most pronounced reduction was observed for the B.1.351 (Beta; 3.6-fold) and P.1 (Gamma; 3.4-fold) variants that contain similar mutations in the receptor-binding domain (RBD) while only a 1.6-fold reduction was observed for the widely spreading B.1.617.2 (Delta) variant.

Competing Interest Statement

All authors are employed by Janssen Vaccine & Prevention B.V., Janssen Pharmaceutical Companies of Johnson & Johnson.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted July 01, 2021.
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Ad26.COV2.S elicited neutralizing activity against Delta and other SARS-CoV-2 variants of concern
Mandy Jongeneelen, Krisztian Kaszas, Daniel Veldman, Jeroen Huizingh, Remko van der Vlugt, Theo Schouten, David Zuijdgeest, Taco Uil, Griet van Roey, Nuria Guimera, Marjon Navis, Rinke Bos, Mathieu le Gars, Jerald Sadoff, Leacky Muchene, Jarek Juraszek, Johannes PM Langedijk, Ronald Vogels, Jerome Custers, Hanneke Schuitemaker, Boerries Brandenburg
bioRxiv 2021.07.01.450707; doi: https://doi.org/10.1101/2021.07.01.450707
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Ad26.COV2.S elicited neutralizing activity against Delta and other SARS-CoV-2 variants of concern
Mandy Jongeneelen, Krisztian Kaszas, Daniel Veldman, Jeroen Huizingh, Remko van der Vlugt, Theo Schouten, David Zuijdgeest, Taco Uil, Griet van Roey, Nuria Guimera, Marjon Navis, Rinke Bos, Mathieu le Gars, Jerald Sadoff, Leacky Muchene, Jarek Juraszek, Johannes PM Langedijk, Ronald Vogels, Jerome Custers, Hanneke Schuitemaker, Boerries Brandenburg
bioRxiv 2021.07.01.450707; doi: https://doi.org/10.1101/2021.07.01.450707

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