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TGFβ2 regulates human trabecular meshwork cell contractility via ERK and ROCK pathways with distinct signaling crosstalk dependent on the culture substrate

Haiyan Li, Jessica L. Henty-Ridilla, Preethi S. Ganapathy, View ORCID ProfileSamuel Herberg
doi: https://doi.org/10.1101/2021.07.01.450718
Haiyan Li
aDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA
bDepartment of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
eBioInspired Institute, Syracuse University, Syracuse, NY 13244, USA
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Jessica L. Henty-Ridilla
cDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
dDepartment of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
eBioInspired Institute, Syracuse University, Syracuse, NY 13244, USA
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Preethi S. Ganapathy
aDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA
dDepartment of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
eBioInspired Institute, Syracuse University, Syracuse, NY 13244, USA
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Samuel Herberg
aDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA
bDepartment of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
cDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
eBioInspired Institute, Syracuse University, Syracuse, NY 13244, USA
fDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA
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  • ORCID record for Samuel Herberg
  • For correspondence: herbergs@upstate.edu
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Article Information

doi 
https://doi.org/10.1101/2021.07.01.450718
History 
  • July 1, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Haiyan Lia,b,e,
  2. Jessica L. Henty-Ridillac,d,e,
  3. Preethi S. Ganapathya,d,e and
  4. Samuel Herberga,b,c,e,f,*
  1. aDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA
  2. bDepartment of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
  3. cDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
  4. dDepartment of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
  5. eBioInspired Institute, Syracuse University, Syracuse, NY 13244, USA
  6. fDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA
  1. ↵*To whom correspondence should be addressed: Samuel Herberg, PhD, Assistant Professor; Department of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, 505 Irving Avenue, Neuroscience Research Building Room 4609, Syracuse, NY 13210, USA, email: herbergs{at}upstate.edu
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TGFβ2 regulates human trabecular meshwork cell contractility via ERK and ROCK pathways with distinct signaling crosstalk dependent on the culture substrate
Haiyan Li, Jessica L. Henty-Ridilla, Preethi S. Ganapathy, Samuel Herberg
bioRxiv 2021.07.01.450718; doi: https://doi.org/10.1101/2021.07.01.450718
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TGFβ2 regulates human trabecular meshwork cell contractility via ERK and ROCK pathways with distinct signaling crosstalk dependent on the culture substrate
Haiyan Li, Jessica L. Henty-Ridilla, Preethi S. Ganapathy, Samuel Herberg
bioRxiv 2021.07.01.450718; doi: https://doi.org/10.1101/2021.07.01.450718

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