TGFβ2 regulates human trabecular meshwork cell contractility via ERK and ROCK pathways with distinct signaling crosstalk dependent on the culture substrate

Haiyan Li; Jessica L. Henty-Ridilla; Preethi S. Ganapathy; Samuel Herberg

doi:10.1101/2021.07.01.450718

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TGFβ2 regulates human trabecular meshwork cell contractility via ERK and ROCK pathways with distinct signaling crosstalk dependent on the culture substrate

Haiyan Li, Jessica L. Henty-Ridilla, Preethi S. Ganapathy, View ORCID ProfileSamuel Herberg

doi: https://doi.org/10.1101/2021.07.01.450718

Haiyan Li

aDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA

bDepartment of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA

eBioInspired Institute, Syracuse University, Syracuse, NY 13244, USA

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Jessica L. Henty-Ridilla

cDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA

dDepartment of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA

eBioInspired Institute, Syracuse University, Syracuse, NY 13244, USA

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Preethi S. Ganapathy

aDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA

dDepartment of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA

eBioInspired Institute, Syracuse University, Syracuse, NY 13244, USA

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Samuel Herberg

aDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA

bDepartment of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA

cDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA

eBioInspired Institute, Syracuse University, Syracuse, NY 13244, USA

fDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA

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ORCID record for Samuel Herberg
For correspondence: herbergs@upstate.edu

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Posted July 01, 2021.

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TGFβ2 regulates human trabecular meshwork cell contractility via ERK and ROCK pathways with distinct signaling crosstalk dependent on the culture substrate

Haiyan Li, Jessica L. Henty-Ridilla, Preethi S. Ganapathy, Samuel Herberg

bioRxiv 2021.07.01.450718; doi: https://doi.org/10.1101/2021.07.01.450718

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TGFβ2 regulates human trabecular meshwork cell contractility via ERK and ROCK pathways with distinct signaling crosstalk dependent on the culture substrate

Haiyan Li, Jessica L. Henty-Ridilla, Preethi S. Ganapathy, Samuel Herberg

bioRxiv 2021.07.01.450718; doi: https://doi.org/10.1101/2021.07.01.450718

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