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CRISPR/Cas9 deletions induce adverse on-target genomic effects leading to functional DNA in human cells

View ORCID ProfileKeyi Geng, Lara G. Merino, Linda Wedemann, Aniek Martens, Małgorzata Sobota, Yerma P. Sanchez, Jonas Nørskov Søndergaard, Robert J. White, View ORCID ProfileClaudia Kutter
doi: https://doi.org/10.1101/2021.07.01.450727
Keyi Geng
1Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Science for Life Laboratory, Sweden
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  • ORCID record for Keyi Geng
Lara G. Merino
1Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Science for Life Laboratory, Sweden
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Linda Wedemann
1Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Science for Life Laboratory, Sweden
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Aniek Martens
1Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Science for Life Laboratory, Sweden
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Małgorzata Sobota
1Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Science for Life Laboratory, Sweden
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Yerma P. Sanchez
1Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Science for Life Laboratory, Sweden
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Jonas Nørskov Søndergaard
1Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Science for Life Laboratory, Sweden
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Robert J. White
2University of York, Department of Biology, York, United Kingdom
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Claudia Kutter
1Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Science for Life Laboratory, Sweden
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  • ORCID record for Claudia Kutter
  • For correspondence: claudia.kutter@ki.se
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Posted April 25, 2022.
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CRISPR/Cas9 deletions induce adverse on-target genomic effects leading to functional DNA in human cells
Keyi Geng, Lara G. Merino, Linda Wedemann, Aniek Martens, Małgorzata Sobota, Yerma P. Sanchez, Jonas Nørskov Søndergaard, Robert J. White, Claudia Kutter
bioRxiv 2021.07.01.450727; doi: https://doi.org/10.1101/2021.07.01.450727
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CRISPR/Cas9 deletions induce adverse on-target genomic effects leading to functional DNA in human cells
Keyi Geng, Lara G. Merino, Linda Wedemann, Aniek Martens, Małgorzata Sobota, Yerma P. Sanchez, Jonas Nørskov Søndergaard, Robert J. White, Claudia Kutter
bioRxiv 2021.07.01.450727; doi: https://doi.org/10.1101/2021.07.01.450727

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