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A model of rapid homeostatic plasticity accounts for hidden, long-lasting changes in a neuronal circuit after exposure to high potassium

View ORCID ProfileMara C.P. Rue, View ORCID ProfileLeandro Alonso, View ORCID ProfileEve Marder
doi: https://doi.org/10.1101/2021.07.01.450770
Mara C.P. Rue
Biology Department and Volen Center, Brandeis University, Waltham, MA 02454
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Leandro Alonso
Biology Department and Volen Center, Brandeis University, Waltham, MA 02454
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Eve Marder
Biology Department and Volen Center, Brandeis University, Waltham, MA 02454
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  • ORCID record for Eve Marder
  • For correspondence: marder@brandeis.edu
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Abstract

Neural circuits must both function reliably and flexibly adapt to changes in their environment. We studied how both biological neurons and computational models respond to high potassium concentrations. Pyloric neurons of the crab stomatogastric ganglion (STG) initially become quiescent, then recover spiking activity in high potassium saline. The neurons retain this adaptation and recover more rapidly in subsequent high potassium applications, even after hours in control saline. We constructed a novel activity-dependent computational model that qualitatively captures these results. In this model, regulation of conductances is gated on and off depending on how far the neuron is from its target activity. This allows the model neuron to retain a trace of past perturbations even after it returns to its target activity in control conditions. Thus, perturbation, followed by recovery of normal activity, can hide cryptic changes in neuronal properties that are only revealed by subsequent perturbations.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • The authors declare no conflicts of interest.

  • Funding: Supported by NIH R35 NS097343 (EM, LA) and F31-NS113383 (MR)

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted July 01, 2021.
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A model of rapid homeostatic plasticity accounts for hidden, long-lasting changes in a neuronal circuit after exposure to high potassium
Mara C.P. Rue, Leandro Alonso, Eve Marder
bioRxiv 2021.07.01.450770; doi: https://doi.org/10.1101/2021.07.01.450770
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A model of rapid homeostatic plasticity accounts for hidden, long-lasting changes in a neuronal circuit after exposure to high potassium
Mara C.P. Rue, Leandro Alonso, Eve Marder
bioRxiv 2021.07.01.450770; doi: https://doi.org/10.1101/2021.07.01.450770

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