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Network-based identification and pharmacological targeting of host cell master regulators induced by SARS-CoV-2 infection
Pasquale Laise, Megan L. Stanifer, Gideon Bosker, Xiaoyun Sun, Sergio Triana, Patricio Doldan, Federico La Manna, Marta De Menna, Ronald B. Realubit, Sergey Pampou, Charles Karan, View ORCID ProfileTheodore Alexandrov, Marianna Kruithof-de Julio, View ORCID ProfileAndrea Califano, Steeve Boulant, View ORCID ProfileMariano J. Alvarez
doi: https://doi.org/10.1101/2021.07.03.451001
Pasquale Laise
1DarwinHealth Inc, New York, NY, USA
2Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA
Megan L. Stanifer
3Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Germany
Gideon Bosker
1DarwinHealth Inc, New York, NY, USA
Xiaoyun Sun
1DarwinHealth Inc, New York, NY, USA
Sergio Triana
4Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
5Collaboration for joint PhD degree between EMBL and Heidelberg University, Faculty of Biosciences, Germany
Patricio Doldan
6Department of Infectious Diseases, Virology, Heidelberg University Hospital, Germany
7Research Group “Cellular Polarity and Viral Infection”, German Cancer Research Center (DKFZ), Heidelberg, Germany
Federico La Manna
8Department for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland
9Translational Organoid Models, Department for BioMedical Research, University of Bern, Bern, Switzerland
10Bern Center for Precision Medicine, University of Bern and Inselspital, Bern, Switzerland
11Department of Urology, Inselspital, Bern University Hospital, Bern, Switzerland
Marta De Menna
8Department for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland
9Translational Organoid Models, Department for BioMedical Research, University of Bern, Bern, Switzerland
10Bern Center for Precision Medicine, University of Bern and Inselspital, Bern, Switzerland
11Department of Urology, Inselspital, Bern University Hospital, Bern, Switzerland
Ronald B. Realubit
2Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA
Sergey Pampou
2Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA
Charles Karan
2Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA
Theodore Alexandrov
4Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
12Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
13Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory, Heidelberg, Germany
Marianna Kruithof-de Julio
8Department for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland
9Translational Organoid Models, Department for BioMedical Research, University of Bern, Bern, Switzerland
10Bern Center for Precision Medicine, University of Bern and Inselspital, Bern, Switzerland
11Department of Urology, Inselspital, Bern University Hospital, Bern, Switzerland
Andrea Califano
2Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA
14Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA
15Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA
16Department of Biochemistry & Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA
17Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USA
Steeve Boulant
6Department of Infectious Diseases, Virology, Heidelberg University Hospital, Germany
7Research Group “Cellular Polarity and Viral Infection”, German Cancer Research Center (DKFZ), Heidelberg, Germany
Mariano J. Alvarez
1DarwinHealth Inc, New York, NY, USA
2Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA
Posted July 04, 2021.
Network-based identification and pharmacological targeting of host cell master regulators induced by SARS-CoV-2 infection
Pasquale Laise, Megan L. Stanifer, Gideon Bosker, Xiaoyun Sun, Sergio Triana, Patricio Doldan, Federico La Manna, Marta De Menna, Ronald B. Realubit, Sergey Pampou, Charles Karan, Theodore Alexandrov, Marianna Kruithof-de Julio, Andrea Califano, Steeve Boulant, Mariano J. Alvarez
bioRxiv 2021.07.03.451001; doi: https://doi.org/10.1101/2021.07.03.451001
Network-based identification and pharmacological targeting of host cell master regulators induced by SARS-CoV-2 infection
Pasquale Laise, Megan L. Stanifer, Gideon Bosker, Xiaoyun Sun, Sergio Triana, Patricio Doldan, Federico La Manna, Marta De Menna, Ronald B. Realubit, Sergey Pampou, Charles Karan, Theodore Alexandrov, Marianna Kruithof-de Julio, Andrea Califano, Steeve Boulant, Mariano J. Alvarez
bioRxiv 2021.07.03.451001; doi: https://doi.org/10.1101/2021.07.03.451001
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