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Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
View ORCID ProfileMilton Pividori, Sumei Lu, View ORCID ProfileBinglan Li, View ORCID ProfileChun Su, Matthew E. Johnson, Wei-Qi Wei, View ORCID ProfileQiping Feng, Bahram Namjou, View ORCID ProfileKrzysztof Kiryluk, Iftikhar Kullo, Yuan Luo, Blair D. Sullivan, View ORCID ProfileBenjamin F. Voight, View ORCID ProfileCarsten Skarke, View ORCID ProfileMarylyn D. Ritchie, View ORCID ProfileStruan F.A. Grant, View ORCID ProfileCasey S. Greene
doi: https://doi.org/10.1101/2021.07.05.450786
Milton Pividori
1Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Sumei Lu
2Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA
Binglan Li
3Department of Biomedical Data Science, Stanford University, Stanford, CA, USA
Chun Su
2Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA
Matthew E. Johnson
2Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA
Wei-Qi Wei
4Vanderbilt University Medical Center
Qiping Feng
4Vanderbilt University Medical Center
Bahram Namjou
5Cincinnati Children’s Hospital Medical Center
Krzysztof Kiryluk
6Department of Medicine, Division of Nephrology, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York
Iftikhar Kullo
7Mayo Clinic
Yuan Luo
8Northwestern University
Blair D. Sullivan
9School of Computing, University of Utah, Salt Lake City, UT, USA
Benjamin F. Voight
1Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
10Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
11Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Carsten Skarke
12Institute for Translational Medicine and Therapeutics, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Marylyn D. Ritchie
1Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Struan F.A. Grant
2Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA
13Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA
14Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA
Casey S. Greene
15Center for Health AI, University of Colorado School of Medicine, Aurora, CO 80045, USA
16Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, USA
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Posted August 05, 2021.
Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
Milton Pividori, Sumei Lu, Binglan Li, Chun Su, Matthew E. Johnson, Wei-Qi Wei, Qiping Feng, Bahram Namjou, Krzysztof Kiryluk, Iftikhar Kullo, Yuan Luo, Blair D. Sullivan, Benjamin F. Voight, Carsten Skarke, Marylyn D. Ritchie, Struan F.A. Grant, Casey S. Greene
bioRxiv 2021.07.05.450786; doi: https://doi.org/10.1101/2021.07.05.450786
Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
Milton Pividori, Sumei Lu, Binglan Li, Chun Su, Matthew E. Johnson, Wei-Qi Wei, Qiping Feng, Bahram Namjou, Krzysztof Kiryluk, Iftikhar Kullo, Yuan Luo, Blair D. Sullivan, Benjamin F. Voight, Carsten Skarke, Marylyn D. Ritchie, Struan F.A. Grant, Casey S. Greene
bioRxiv 2021.07.05.450786; doi: https://doi.org/10.1101/2021.07.05.450786
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