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The BLMP-1 transcription factor promotes oscillatory gene expression to achieve timely molting

View ORCID ProfileYannick P. Hauser, View ORCID ProfileMilou W.M. Meeuse, View ORCID ProfileDimos Gaidatzis, View ORCID ProfileHelge Großhans
doi: https://doi.org/10.1101/2021.07.05.450828
Yannick P. Hauser
1Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel
2University of Basel, Petersplatz 1, CH-4001 Basel
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Milou W.M. Meeuse
1Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel
2University of Basel, Petersplatz 1, CH-4001 Basel
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Dimos Gaidatzis
1Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel
3Swiss Institute of Bioinformatics, Basel, Switzerland
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Helge Großhans
1Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel
2University of Basel, Petersplatz 1, CH-4001 Basel
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  • For correspondence: helge.grosshans@fmi.ch
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Abstract

Gene expression oscillators can coordinate developmental events in space and time. In C. elegans, a gene expression oscillator directs rhythmic accumulation of ∼25% of the transcriptome, and thus thousands of transcripts, presumably to control molting, a process of rhythmic skin regeneration. The mechanism and organization of the oscillator are not known. Here, we report that rhythmic RNA polymerase II recruitment to promoters produces transcript level oscillations. We identify BLMP-1, orthologous to the mammalian transcription repressor PRDM1, as a rhythmically accumulating transcription factor that is required for timely molting, and oscillatory gene expression. We propose a dual function for BLMP-1 in shaping oscillatory gene expression and coupling it to a set of direct targets, which ensures cuticular integrity. With mammalian PRDM1/BLIMP1 promoting regular cycles of postnatal hair follicle regeneration, our findings point to the possible existence of a fundamentally conserved clock mechanism in control of rhythmic skin regeneration.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted July 05, 2021.
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The BLMP-1 transcription factor promotes oscillatory gene expression to achieve timely molting
Yannick P. Hauser, Milou W.M. Meeuse, Dimos Gaidatzis, Helge Großhans
bioRxiv 2021.07.05.450828; doi: https://doi.org/10.1101/2021.07.05.450828
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The BLMP-1 transcription factor promotes oscillatory gene expression to achieve timely molting
Yannick P. Hauser, Milou W.M. Meeuse, Dimos Gaidatzis, Helge Großhans
bioRxiv 2021.07.05.450828; doi: https://doi.org/10.1101/2021.07.05.450828

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