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Micronutrient supplements with iron promote disruptive protozoan and fungal communities in the developing infant gut

View ORCID ProfileAna Popovic, View ORCID ProfileCeline Bourdon, View ORCID ProfilePauline W. Wang, View ORCID ProfileDavid S. Guttman, Sajid Soofi, View ORCID ProfileZulfiqar A. Bhutta, View ORCID ProfileRobert H. J. Bandsma, View ORCID ProfileJohn Parkinson, View ORCID ProfileLisa G. Pell
doi: https://doi.org/10.1101/2021.07.06.451346
Ana Popovic
1Program in Molecular Medicine, Hospital for Sick Children Research Institute
2Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
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Celine Bourdon
3Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada
4Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada
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Pauline W. Wang
5Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada
6Centre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada
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David S. Guttman
5Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada
6Centre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada
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Sajid Soofi
7Center of Excellence in Women and Child Health, the Aga Khan University, Karachi, Pakistan
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Zulfiqar A. Bhutta
4Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada
7Center of Excellence in Women and Child Health, the Aga Khan University, Karachi, Pakistan
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Robert H. J. Bandsma
3Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada
4Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada
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John Parkinson
1Program in Molecular Medicine, Hospital for Sick Children Research Institute
2Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
8Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
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  • For correspondence: john.parkinson@utoronto.ca
Lisa G. Pell
4Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada
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  • ORCID record for Lisa G. Pell
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Abstract

Supplementation with micronutrients, including vitamins, iron and zinc, is a key strategy to alleviate child malnutrition. However, adverse events resulting in gastrointestinal disorders, largely associated with iron, has resulted in ongoing debate over their administration. To better understand their impact on gut microbiota, we analysed the bacterial, protozoal, fungal and helminth communities of stool samples collected from children that had previously been recruited to a cluster randomized controlled trial of micronutrient supplementation in Pakistan. We show that while bacterial diversity was reduced in supplemented children, vitamins and iron may promote colonization with distinct protozoa and mucormycetes, whereas the addition of zinc ameliorates this effect. In addition to supplements, residence in a rural versus urban setting is an important determinant of eukaryotic composition. We suggest that the risks and benefits of such interventions may be mediated in part through eukaryotic communities, in a manner dependent on setting.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • We have included a Code Availability statement with a link to our GitHub repository.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted July 09, 2021.
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Micronutrient supplements with iron promote disruptive protozoan and fungal communities in the developing infant gut
Ana Popovic, Celine Bourdon, Pauline W. Wang, David S. Guttman, Sajid Soofi, Zulfiqar A. Bhutta, Robert H. J. Bandsma, John Parkinson, Lisa G. Pell
bioRxiv 2021.07.06.451346; doi: https://doi.org/10.1101/2021.07.06.451346
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Micronutrient supplements with iron promote disruptive protozoan and fungal communities in the developing infant gut
Ana Popovic, Celine Bourdon, Pauline W. Wang, David S. Guttman, Sajid Soofi, Zulfiqar A. Bhutta, Robert H. J. Bandsma, John Parkinson, Lisa G. Pell
bioRxiv 2021.07.06.451346; doi: https://doi.org/10.1101/2021.07.06.451346

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