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Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells

Alan Ianeselli, Damla Tetiker, Julian Stein, Alexandra Kühnlein, Christof Mast, Dieter Braun, View ORCID ProfileT-Y Dora Tang
doi: https://doi.org/10.1101/2021.07.08.451414
Alan Ianeselli
1Systems Biophysics, Ludwig Maximilian University Munich, Amalienstraße 54, 80799 München, Germany
2Center for NanoScience (CeNS), Ludwig Maximilian University, Amalienstraße 54, 80799 München, Germany
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Damla Tetiker
1Systems Biophysics, Ludwig Maximilian University Munich, Amalienstraße 54, 80799 München, Germany
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Julian Stein
1Systems Biophysics, Ludwig Maximilian University Munich, Amalienstraße 54, 80799 München, Germany
2Center for NanoScience (CeNS), Ludwig Maximilian University, Amalienstraße 54, 80799 München, Germany
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Alexandra Kühnlein
1Systems Biophysics, Ludwig Maximilian University Munich, Amalienstraße 54, 80799 München, Germany
2Center for NanoScience (CeNS), Ludwig Maximilian University, Amalienstraße 54, 80799 München, Germany
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Christof Mast
1Systems Biophysics, Ludwig Maximilian University Munich, Amalienstraße 54, 80799 München, Germany
2Center for NanoScience (CeNS), Ludwig Maximilian University, Amalienstraße 54, 80799 München, Germany
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Dieter Braun
1Systems Biophysics, Ludwig Maximilian University Munich, Amalienstraße 54, 80799 München, Germany
2Center for NanoScience (CeNS), Ludwig Maximilian University, Amalienstraße 54, 80799 München, Germany
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  • For correspondence: tang@mpi-cbg.de dieter.braun@lmu.de
T-Y Dora Tang
3Max-Planck institute for Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany
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  • ORCID record for T-Y Dora Tang
  • For correspondence: tang@mpi-cbg.de dieter.braun@lmu.de
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Abstract

Key requirements for the first cells on Earth include the ability to compartmentalize and evolve. Compartmentalization spatially localizes biomolecules from a dilute pool and an evolving cell which grows and divides permits mixing and propagation of information to daughter cells. Complex coacervate microdroplets are excellent candidates as primordial cells with the ability to partition and concentrate molecules into their core and support primitive and complex biochemical reactions. However, the evolution of coacervate protocells by fusion, growth and fission has not yet been demonstrated. In this work, a primordial environment initiated the evolution of coacervate-based protocells. Gas bubbles inside heated rock pores perturb the coacervate protocell distribution and drive the growth, fusion, division and selection of coacervate microdroplets. This setting provides a primordial non-equilibrium environment. Our findings describe how common gas bubbles within heated rock pores induce the early evolution processes of coacervate-based protocells, providing a compelling scenario for the evolution of membrane-free coacervate microdroplets on the early Earth.

Competing Interest Statement

The authors have declared no competing interest.

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Posted July 09, 2021.
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Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells
Alan Ianeselli, Damla Tetiker, Julian Stein, Alexandra Kühnlein, Christof Mast, Dieter Braun, T-Y Dora Tang
bioRxiv 2021.07.08.451414; doi: https://doi.org/10.1101/2021.07.08.451414
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Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells
Alan Ianeselli, Damla Tetiker, Julian Stein, Alexandra Kühnlein, Christof Mast, Dieter Braun, T-Y Dora Tang
bioRxiv 2021.07.08.451414; doi: https://doi.org/10.1101/2021.07.08.451414

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