Altered costimulatory signals and hypoxia support chromatin landscapes limiting the functional potential of exhausted T cells in cancer

B. Rhodes Ford; Natalie L. Rittenhouse; Nicole E. Scharping; Paolo D. A. Vignali; Andrew T. Frisch; Ronal Peralta; Greg M. Delgoffe; Amanda C. Poholek

doi:10.1101/2021.07.11.451947

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Altered costimulatory signals and hypoxia support chromatin landscapes limiting the functional potential of exhausted T cells in cancer

View ORCID ProfileB. Rhodes Ford, View ORCID ProfileNatalie L. Rittenhouse, View ORCID ProfileNicole E. Scharping, View ORCID ProfilePaolo D. A. Vignali, View ORCID ProfileAndrew T. Frisch, View ORCID ProfileRonal Peralta, View ORCID ProfileGreg M. Delgoffe, View ORCID ProfileAmanda C. Poholek

doi: https://doi.org/10.1101/2021.07.11.451947

B. Rhodes Ford

1Division of Pediatric Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh PA, 15260, USA

2Department of Immunology, University of Pittsburgh, Pittsburgh PA, 15260, USA

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Natalie L. Rittenhouse

1Division of Pediatric Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh PA, 15260, USA

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ORCID record for Natalie L. Rittenhouse

Nicole E. Scharping

2Department of Immunology, University of Pittsburgh, Pittsburgh PA, 15260, USA

3Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh PA, 15260, USA

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ORCID record for Nicole E. Scharping

Paolo D. A. Vignali

2Department of Immunology, University of Pittsburgh, Pittsburgh PA, 15260, USA

3Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh PA, 15260, USA

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Andrew T. Frisch

2Department of Immunology, University of Pittsburgh, Pittsburgh PA, 15260, USA

3Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh PA, 15260, USA

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Ronal Peralta

2Department of Immunology, University of Pittsburgh, Pittsburgh PA, 15260, USA

3Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh PA, 15260, USA

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Greg M. Delgoffe

2Department of Immunology, University of Pittsburgh, Pittsburgh PA, 15260, USA

3Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh PA, 15260, USA

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For correspondence: gdelgoffe@pitt.edu poholeka@pitt.edu

Amanda C. Poholek

1Division of Pediatric Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh PA, 15260, USA

2Department of Immunology, University of Pittsburgh, Pittsburgh PA, 15260, USA

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For correspondence: gdelgoffe@pitt.edu poholeka@pitt.edu

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Posted July 12, 2021.

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Altered costimulatory signals and hypoxia support chromatin landscapes limiting the functional potential of exhausted T cells in cancer

B. Rhodes Ford, Natalie L. Rittenhouse, Nicole E. Scharping, Paolo D. A. Vignali, Andrew T. Frisch, Ronal Peralta, Greg M. Delgoffe, Amanda C. Poholek

bioRxiv 2021.07.11.451947; doi: https://doi.org/10.1101/2021.07.11.451947

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Altered costimulatory signals and hypoxia support chromatin landscapes limiting the functional potential of exhausted T cells in cancer

B. Rhodes Ford, Natalie L. Rittenhouse, Nicole E. Scharping, Paolo D. A. Vignali, Andrew T. Frisch, Ronal Peralta, Greg M. Delgoffe, Amanda C. Poholek

bioRxiv 2021.07.11.451947; doi: https://doi.org/10.1101/2021.07.11.451947

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