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MetaFun: Unveiling sex differences in multiple omics studies through comprehensive functional meta-analysis

View ORCID ProfilePablo Malmierca-Merlo, View ORCID ProfileRubén Sánchez-Garcia, View ORCID ProfileRubén Grillo-Risco, View ORCID ProfileIrene Pérez-Díez, View ORCID ProfileJosé F. Català-Senent, View ORCID ProfileMaría de la Iglesia-Vayá, View ORCID ProfileMarta R. Hidalgo, View ORCID ProfileFrancisco Garcia-Garcia
doi: https://doi.org/10.1101/2021.07.13.451905
Pablo Malmierca-Merlo
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
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  • ORCID record for Pablo Malmierca-Merlo
Rubén Sánchez-Garcia
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
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  • ORCID record for Rubén Sánchez-Garcia
Rubén Grillo-Risco
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
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Irene Pérez-Díez
2Biomedical Imaging Unit FISABIO-CIPF, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana, 46012 Valencia, Spain
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José F. Català-Senent
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
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  • ORCID record for José F. Català-Senent
María de la Iglesia-Vayá
2Biomedical Imaging Unit FISABIO-CIPF, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana, 46012 Valencia, Spain
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Marta R. Hidalgo
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
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  • For correspondence: fgarcia@cipf.es mhidalgo@cipf.es
Francisco Garcia-Garcia
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
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  • ORCID record for Francisco Garcia-Garcia
  • For correspondence: fgarcia@cipf.es mhidalgo@cipf.es
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Abstract

Summary Sex and gender differences in different health scenarios has been thoroughly acknowledged in the literature, and yet, very scarcely analyzed. To fill the gap, here we present MetaFun, which allows to meta-analyze multiple omics datasets with a sex-based perspective, and to combine different datasets to gain major statistical power and to assist the researcher in understanding these sex differences in the diseases under study. Metafun is freely available at bioinfo.cipf.es/metafun Availability and implementation: MetaFun is available under http://bioinfo.cipf.es/metafun. The backend has been implemented in R and Java and the frontend has been developed using Angular.

Supplementary information R code available at https://gitlab.com/ubb-cipf/metafunr

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://bioinfo.cipf.es/metafun

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted July 14, 2021.
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MetaFun: Unveiling sex differences in multiple omics studies through comprehensive functional meta-analysis
Pablo Malmierca-Merlo, Rubén Sánchez-Garcia, Rubén Grillo-Risco, Irene Pérez-Díez, José F. Català-Senent, María de la Iglesia-Vayá, Marta R. Hidalgo, Francisco Garcia-Garcia
bioRxiv 2021.07.13.451905; doi: https://doi.org/10.1101/2021.07.13.451905
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MetaFun: Unveiling sex differences in multiple omics studies through comprehensive functional meta-analysis
Pablo Malmierca-Merlo, Rubén Sánchez-Garcia, Rubén Grillo-Risco, Irene Pérez-Díez, José F. Català-Senent, María de la Iglesia-Vayá, Marta R. Hidalgo, Francisco Garcia-Garcia
bioRxiv 2021.07.13.451905; doi: https://doi.org/10.1101/2021.07.13.451905

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