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MetaFun: Unveiling Sex-based Differences in Multiple Transcriptomic Studies through Comprehensive Functional Meta-analysis

View ORCID ProfilePablo Malmierca-Merlo, View ORCID ProfileRubén Sánchez-Garcia, View ORCID ProfileRubén Grillo-Risco, View ORCID ProfileIrene Pérez-Díez, View ORCID ProfileJosé F. Català-Senent, View ORCID ProfileBorja Gómez-Cabañes, View ORCID ProfileGonzalo Anton-Bernat, View ORCID ProfileHelena Gómez-Martínez, View ORCID ProfileMaría de la Iglesia-Vayá, View ORCID ProfileMarta R. Hidalgo, View ORCID ProfileFrancisco Garcia-Garcia
doi: https://doi.org/10.1101/2021.07.13.451905
Pablo Malmierca-Merlo
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
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  • ORCID record for Pablo Malmierca-Merlo
Rubén Sánchez-Garcia
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
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  • ORCID record for Rubén Sánchez-Garcia
Rubén Grillo-Risco
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
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Irene Pérez-Díez
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
2Biomedical Imaging Unit FISABIO-CIPF, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana, 46012 Valencia, Spain
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José F. Català-Senent
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
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Borja Gómez-Cabañes
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
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Gonzalo Anton-Bernat
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
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  • ORCID record for Gonzalo Anton-Bernat
Helena Gómez-Martínez
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
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  • ORCID record for Helena Gómez-Martínez
María de la Iglesia-Vayá
2Biomedical Imaging Unit FISABIO-CIPF, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana, 46012 Valencia, Spain
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Marta R. Hidalgo
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
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  • For correspondence: fgarcia@cipf.es
Francisco Garcia-Garcia
1Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain
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  • ORCID record for Francisco Garcia-Garcia
  • For correspondence: fgarcia@cipf.es
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Abstract

While sex-based differences in various health scenarios have been thoroughly acknowledged in the literature, we lack a deep analysis of sex as a variable in this context. To fill this knowledge gap, we created MetaFun as an easy-to-use web-based tool to meta-analyze multiple transcriptomic datasets with a sex-based perspective to gain major statistical power and biological soundness. Furthermore, MetaFun can be used to perform case-control meta-analyses, allowing researchers with basic programming skills to access this methodology.

Availability and implementation MetaFun is freely available at http://bioinfo.cipf.es/metafun The back end was implemented in R and Java, and the front end was developed using Angular

Contact fgarcia{at}cipf.es, mhidalgo{at}cipf.es

Supplementary information R code available at https://gitlab.com/ubb-cipf/metafunr

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • improved methods

  • https://bioinfo.cipf.es/metafun

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 15, 2023.
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MetaFun: Unveiling Sex-based Differences in Multiple Transcriptomic Studies through Comprehensive Functional Meta-analysis
Pablo Malmierca-Merlo, Rubén Sánchez-Garcia, Rubén Grillo-Risco, Irene Pérez-Díez, José F. Català-Senent, Borja Gómez-Cabañes, Gonzalo Anton-Bernat, Helena Gómez-Martínez, María de la Iglesia-Vayá, Marta R. Hidalgo, Francisco Garcia-Garcia
bioRxiv 2021.07.13.451905; doi: https://doi.org/10.1101/2021.07.13.451905
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MetaFun: Unveiling Sex-based Differences in Multiple Transcriptomic Studies through Comprehensive Functional Meta-analysis
Pablo Malmierca-Merlo, Rubén Sánchez-Garcia, Rubén Grillo-Risco, Irene Pérez-Díez, José F. Català-Senent, Borja Gómez-Cabañes, Gonzalo Anton-Bernat, Helena Gómez-Martínez, María de la Iglesia-Vayá, Marta R. Hidalgo, Francisco Garcia-Garcia
bioRxiv 2021.07.13.451905; doi: https://doi.org/10.1101/2021.07.13.451905

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