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Large-scale all-optical dissection of motor cortex connectivity reveals a segregated functional organization of mouse forelimb representations

Francesco Resta, View ORCID ProfileElena Montagni, Giuseppe de Vito, Alessandro Scaglione, View ORCID ProfileAnna Letizia Allegra Mascaro, Francesco Saverio Pavone
doi: https://doi.org/10.1101/2021.07.15.452461
Francesco Resta
1European Laboratory for Non-Linear Spectroscopy, University of Florence, Sesto Fiorentino 50019, Italy
2Department of Physics and Astronomy, University of Florence, Sesto Fiorentino 50019, Italy
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  • For correspondence: allegra@lens.unifi.it
Elena Montagni
1European Laboratory for Non-Linear Spectroscopy, University of Florence, Sesto Fiorentino 50019, Italy
2Department of Physics and Astronomy, University of Florence, Sesto Fiorentino 50019, Italy
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  • ORCID record for Elena Montagni
Giuseppe de Vito
1European Laboratory for Non-Linear Spectroscopy, University of Florence, Sesto Fiorentino 50019, Italy
3Department of Neuroscience, Psychology, Pharmacology and Child Health (NEUROFARBA), University of Florence, Florence 50139, Italy
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Alessandro Scaglione
1European Laboratory for Non-Linear Spectroscopy, University of Florence, Sesto Fiorentino 50019, Italy
2Department of Physics and Astronomy, University of Florence, Sesto Fiorentino 50019, Italy
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Anna Letizia Allegra Mascaro
1European Laboratory for Non-Linear Spectroscopy, University of Florence, Sesto Fiorentino 50019, Italy
4Neuroscience Institute, National Research Council, Pisa 56124, Italy
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Francesco Saverio Pavone
1European Laboratory for Non-Linear Spectroscopy, University of Florence, Sesto Fiorentino 50019, Italy
2Department of Physics and Astronomy, University of Florence, Sesto Fiorentino 50019, Italy
5National Institute of Optics, National Research Council, Sesto Fiorentino 50019, Italy
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ABSTRACT

In rodent motor cortex, the rostral forelimb area (RFA) and the caudal forelimb area (CFA) are major actors in orchestrating the control of forelimb complex movements. However, their intrinsic connections and reciprocal functional organization are still unclear, limiting our understanding of how the brain coordinates and executes voluntary movements. Here we causally probed cortical connectivity and activation patterns triggered by transcranial optogenetic stimulation of ethologically relevant complex movements exploiting a novel large-scale all-optical method in awake mice. Results show specific activation features for each movement class, providing evidence for a segregated functional organization of CFA and RFA. Importantly, we identified a second discrete lateral grasping representation area, namely lateral forelimb area (LFA), with unique connectivity and activation patterns. Therefore, we propose the LFA as a distinct motor representation in the forelimb somatotopic motor map.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted July 15, 2021.
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Large-scale all-optical dissection of motor cortex connectivity reveals a segregated functional organization of mouse forelimb representations
Francesco Resta, Elena Montagni, Giuseppe de Vito, Alessandro Scaglione, Anna Letizia Allegra Mascaro, Francesco Saverio Pavone
bioRxiv 2021.07.15.452461; doi: https://doi.org/10.1101/2021.07.15.452461
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Large-scale all-optical dissection of motor cortex connectivity reveals a segregated functional organization of mouse forelimb representations
Francesco Resta, Elena Montagni, Giuseppe de Vito, Alessandro Scaglione, Anna Letizia Allegra Mascaro, Francesco Saverio Pavone
bioRxiv 2021.07.15.452461; doi: https://doi.org/10.1101/2021.07.15.452461

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