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BET protein inhibition regulates macrophage chromatin accessibility and microbiota-dependent colitis
View ORCID ProfileMichelle Hoffner O’Connor, View ORCID ProfileAna Berglind, View ORCID ProfileMeaghan M. Kennedy, View ORCID ProfileBenjamin P. Keith, Zachary J. Lynch, View ORCID ProfileMatthew R. Schaner, View ORCID ProfileErin C. Steinbach, Jeremy Herzog, Omar K. Trad, View ORCID ProfileWilliam R. Jeck, View ORCID ProfileJanelle C. Arthur, View ORCID ProfileR. Balfour Sartor, View ORCID ProfileTerrence S. Furey, View ORCID ProfileShehzad Z. Sheikh
doi: https://doi.org/10.1101/2021.07.15.452570
Michelle Hoffner O’Connor
1Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
2Department of Genetics, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Ana Berglind
1Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
2Department of Genetics, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Meaghan M. Kennedy
1Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
3Department of Genetics, Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Benjamin P. Keith
1Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
3Department of Genetics, Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Zachary J. Lynch
1Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Matthew R. Schaner
1Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Erin C. Steinbach
1Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
4Department of Pediatrics, Division of Gastroenterology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Jeremy Herzog
1Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Omar K. Trad
1Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
William R. Jeck
5Department of Pathology, Duke University, Durham, North Carolina, USA
Janelle C. Arthur
1Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
6Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
7Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
R. Balfour Sartor
1Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Terrence S. Furey
1Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
3Department of Genetics, Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
8Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Shehzad Z. Sheikh
1Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
2Department of Genetics, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Posted July 16, 2021.
BET protein inhibition regulates macrophage chromatin accessibility and microbiota-dependent colitis
Michelle Hoffner O’Connor, Ana Berglind, Meaghan M. Kennedy, Benjamin P. Keith, Zachary J. Lynch, Matthew R. Schaner, Erin C. Steinbach, Jeremy Herzog, Omar K. Trad, William R. Jeck, Janelle C. Arthur, R. Balfour Sartor, Terrence S. Furey, Shehzad Z. Sheikh
bioRxiv 2021.07.15.452570; doi: https://doi.org/10.1101/2021.07.15.452570
BET protein inhibition regulates macrophage chromatin accessibility and microbiota-dependent colitis
Michelle Hoffner O’Connor, Ana Berglind, Meaghan M. Kennedy, Benjamin P. Keith, Zachary J. Lynch, Matthew R. Schaner, Erin C. Steinbach, Jeremy Herzog, Omar K. Trad, William R. Jeck, Janelle C. Arthur, R. Balfour Sartor, Terrence S. Furey, Shehzad Z. Sheikh
bioRxiv 2021.07.15.452570; doi: https://doi.org/10.1101/2021.07.15.452570
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