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CLARA: A web portal for interactive exploration of the cardiovascular cellular landscape in health and disease

Malathi S.I. Dona, Ian Hsu, Thushara S. Rathnayake, Gabriella E. Farrugia, Taylah L. Gaynor, Malvika Kharbanda, Daniel A. Skelly, View ORCID ProfileAlexander R. Pinto
doi: https://doi.org/10.1101/2021.07.18.452862
Malathi S.I. Dona
1Baker Heart and Diabetes Research Institute, Melbourne, Victoria, Australia
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Ian Hsu
1Baker Heart and Diabetes Research Institute, Melbourne, Victoria, Australia
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Thushara S. Rathnayake
1Baker Heart and Diabetes Research Institute, Melbourne, Victoria, Australia
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Gabriella E. Farrugia
1Baker Heart and Diabetes Research Institute, Melbourne, Victoria, Australia
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Taylah L. Gaynor
1Baker Heart and Diabetes Research Institute, Melbourne, Victoria, Australia
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Malvika Kharbanda
1Baker Heart and Diabetes Research Institute, Melbourne, Victoria, Australia
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Daniel A. Skelly
2The Jackson Laboratory, Bar Harbor, ME, USA
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Alexander R. Pinto
1Baker Heart and Diabetes Research Institute, Melbourne, Victoria, Australia
3Centre for Cardiovascular Biology and Disease Research, La Trobe University, Melbourne Victoria, Australia
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  • ORCID record for Alexander R. Pinto
  • For correspondence: alex.pinto@baker.edu.au
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ABSTRACT

Mammalian cardiovascular tissues are comprised of complex and diverse collections of cells. Recent advances in single-cell profiling technologies have accelerated our understanding of tissue cellularity and the molecular networks that orchestrate cardiovascular development, maintain homeostasis, and are disrupted in pathological states. Despite the rapid development and application of these technologies, many cardiac single-cell functional genomics datasets remain inaccessible for most cardiovascular biologists. Access to custom visual representations of the data, including querying changes in cellular phenotypes and interactions in diverse contexts, remains unavailable in publicly accessible data portals. Visualizing data is also challenging for scientists without expertise in processing single-cell genomic data. Here we present CLARA—CardiovascuLAR Atlas—a web portal facilitating exploration of the cardiovascular cellular landscape. Using mouse and human single-cell transcriptomic datasets, CLARA enables scientists unfamiliar with single-cell-omic data analysis approaches to examine gene expression patterns and the cell population dynamics of cardiac cells in a range of contexts. The web-application also enables investigation of intercellular interactions that form the cardiac cellular niche. CLARA is designed for ease-of-use and we anticipate that the portal will aid deeper exploration of cardiovascular cellular landscapes in the context of development, homeostasis and disease. CLARA is freely available at https://clara.baker.edu.au.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted July 19, 2021.
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CLARA: A web portal for interactive exploration of the cardiovascular cellular landscape in health and disease
Malathi S.I. Dona, Ian Hsu, Thushara S. Rathnayake, Gabriella E. Farrugia, Taylah L. Gaynor, Malvika Kharbanda, Daniel A. Skelly, Alexander R. Pinto
bioRxiv 2021.07.18.452862; doi: https://doi.org/10.1101/2021.07.18.452862
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CLARA: A web portal for interactive exploration of the cardiovascular cellular landscape in health and disease
Malathi S.I. Dona, Ian Hsu, Thushara S. Rathnayake, Gabriella E. Farrugia, Taylah L. Gaynor, Malvika Kharbanda, Daniel A. Skelly, Alexander R. Pinto
bioRxiv 2021.07.18.452862; doi: https://doi.org/10.1101/2021.07.18.452862

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