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Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants

View ORCID ProfileTakuya Tada, Hao Zhou, Marie I. Samanovic, View ORCID ProfileBelinda M. Dcosta, Amber Cornelius, Mark J. Mulligan, View ORCID ProfileNathaniel R. Landau
doi: https://doi.org/10.1101/2021.07.19.452771
Takuya Tada
1Department of Microbiology, NYU Grossman School of Medicine, New York, NY, USA
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  • ORCID record for Takuya Tada
Hao Zhou
1Department of Microbiology, NYU Grossman School of Medicine, New York, NY, USA
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Marie I. Samanovic
2Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA
3NYU Langone Vaccine Center, NYU Grossman School of Medicine, New York, NY, USA
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Belinda M. Dcosta
1Department of Microbiology, NYU Grossman School of Medicine, New York, NY, USA
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Amber Cornelius
2Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA
3NYU Langone Vaccine Center, NYU Grossman School of Medicine, New York, NY, USA
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Mark J. Mulligan
1Department of Microbiology, NYU Grossman School of Medicine, New York, NY, USA
2Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA
3NYU Langone Vaccine Center, NYU Grossman School of Medicine, New York, NY, USA
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Nathaniel R. Landau
1Department of Microbiology, NYU Grossman School of Medicine, New York, NY, USA
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  • ORCID record for Nathaniel R. Landau
  • For correspondence: nathaniel.landau@med.nyu.edu
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Abstract

The increasing prevalence of SARS-CoV-2 variants has raised concerns regarding possible decreases in vaccine efficacy. Here, neutralizing antibody titers elicited by mRNA-based and an adenoviral vector-based vaccine against variant pseudotyped viruses were compared. BNT162b2 and mRNA-1273-elicited antibodies showed modest neutralization resistance against Beta, Delta, Delta plus and Lambda variants whereas Ad26.COV2.S-elicited antibodies from a significant fraction of vaccinated individuals were of low neutralizing titer (IC50 <50). The data underscore the importance of surveillance for breakthrough infections that result in severe COVID-19 and suggest the benefit of a second immunization following Ad26.COV2.S to increase protection against the variants.

Competing Interest Statement

The authors declare no competing interests except M.J.M. who received research grants from Lilly, Pfizer, and Sanofi, and serves on advisory boards for Pfizer and Meissa Vaccines.

Footnotes

  • We just changed Details of all competing interests.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted August 06, 2021.
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Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants
Takuya Tada, Hao Zhou, Marie I. Samanovic, Belinda M. Dcosta, Amber Cornelius, Mark J. Mulligan, Nathaniel R. Landau
bioRxiv 2021.07.19.452771; doi: https://doi.org/10.1101/2021.07.19.452771
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Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants
Takuya Tada, Hao Zhou, Marie I. Samanovic, Belinda M. Dcosta, Amber Cornelius, Mark J. Mulligan, Nathaniel R. Landau
bioRxiv 2021.07.19.452771; doi: https://doi.org/10.1101/2021.07.19.452771

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