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Crystal structures of taxane-tubulin complexes: Implications for the mechanism of microtubule stabilization by Taxol
View ORCID ProfileAndrea E. Prota, Daniel Lucena-Agell, Yuntao Ma, Juan Estévez-Gallego, Carlos Roca, Fernando Josa-Prado, Kenneth Goossens, Juan Francisco Giménez-Abián, Shuo Li, Ángeles Canales, Katja Bargsten, José Manuel Andreu, Karl-Heinz Altmann, Natacha Olieric, Shinji Kamimura, Tobias Mühlethaler, View ORCID ProfileMaría A. Oliva, View ORCID ProfileMichel O. Steinmetz, Wei-Shuo Fang, View ORCID ProfileJ. Fernando Díaz
doi: https://doi.org/10.1101/2021.07.20.453061
Andrea E. Prota
1Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, CH-5232 Villigen, Switzerland
Daniel Lucena-Agell
2Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain
Yuntao Ma
3State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2A Nan Wei Road, Beijing 100050, China
Juan Estévez-Gallego
2Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain
Carlos Roca
4Department of Organic Chemistry, Faculty of Chemistry, Universidad Complutense de Madrid. Av. Complutense, s/n, 28040 Madrid
Fernando Josa-Prado
2Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain
Kenneth Goossens
2Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain
Juan Francisco Giménez-Abián
2Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain
Shuo Li
3State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2A Nan Wei Road, Beijing 100050, China
Ángeles Canales
2Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain
4Department of Organic Chemistry, Faculty of Chemistry, Universidad Complutense de Madrid. Av. Complutense, s/n, 28040 Madrid
Katja Bargsten
1Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, CH-5232 Villigen, Switzerland
José Manuel Andreu
2Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain
Karl-Heinz Altmann
5Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH, Zürich, Vladimir-Prelog Weg 4, HCI H405, CH-8093 Zürich, Switzerland
Natacha Olieric
1Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, CH-5232 Villigen, Switzerland
Shinji Kamimura
6Department of Biological Sciences, Faculty of Science and Engineering, Chuo University, Kasuga, Bunkyo, Tokyo, Japan
Tobias Mühlethaler
1Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, CH-5232 Villigen, Switzerland
María A. Oliva
2Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain
Michel O. Steinmetz
1Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, CH-5232 Villigen, Switzerland
7University of Basel, Biozentrum, 4056 Basel, Switzerland
Wei-Shuo Fang
3State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2A Nan Wei Road, Beijing 100050, China
J. Fernando Díaz
2Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain
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Posted July 21, 2021.
Crystal structures of taxane-tubulin complexes: Implications for the mechanism of microtubule stabilization by Taxol
Andrea E. Prota, Daniel Lucena-Agell, Yuntao Ma, Juan Estévez-Gallego, Carlos Roca, Fernando Josa-Prado, Kenneth Goossens, Juan Francisco Giménez-Abián, Shuo Li, Ángeles Canales, Katja Bargsten, José Manuel Andreu, Karl-Heinz Altmann, Natacha Olieric, Shinji Kamimura, Tobias Mühlethaler, María A. Oliva, Michel O. Steinmetz, Wei-Shuo Fang, J. Fernando Díaz
bioRxiv 2021.07.20.453061; doi: https://doi.org/10.1101/2021.07.20.453061
Crystal structures of taxane-tubulin complexes: Implications for the mechanism of microtubule stabilization by Taxol
Andrea E. Prota, Daniel Lucena-Agell, Yuntao Ma, Juan Estévez-Gallego, Carlos Roca, Fernando Josa-Prado, Kenneth Goossens, Juan Francisco Giménez-Abián, Shuo Li, Ángeles Canales, Katja Bargsten, José Manuel Andreu, Karl-Heinz Altmann, Natacha Olieric, Shinji Kamimura, Tobias Mühlethaler, María A. Oliva, Michel O. Steinmetz, Wei-Shuo Fang, J. Fernando Díaz
bioRxiv 2021.07.20.453061; doi: https://doi.org/10.1101/2021.07.20.453061
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