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Impaired developmental microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons exacerbates stress responses throughout life
View ORCID ProfileJessica L. Bolton, View ORCID ProfileAnnabel K. Short, View ORCID ProfileShivashankar Othy, View ORCID ProfileCassandra L. Kooiker, Manlin Shao, View ORCID ProfileBenjamin G. Gunn, Jaclyn Beck, View ORCID ProfileXinglong Bai, Stephanie M. Law, View ORCID ProfileJulie C. Savage, Jeremy J. Lambert, View ORCID ProfileDelia Belelli, View ORCID ProfileMarie-Ève Tremblay, View ORCID ProfileMichael D. Cahalan, View ORCID ProfileTallie Z. Baram
doi: https://doi.org/10.1101/2021.07.21.453252
Jessica L. Bolton
1Department of Pediatrics, University of California-Irvine, Irvine, CA, United States of America
2Department of Anatomy / Neurobiology, University of California-Irvine, Irvine, CA, United States of America
Annabel K. Short
1Department of Pediatrics, University of California-Irvine, Irvine, CA, United States of America
2Department of Anatomy / Neurobiology, University of California-Irvine, Irvine, CA, United States of America
Shivashankar Othy
3Department of Physiology & Biophysics, University of California-Irvine, Irvine, CA, United States of America
Cassandra L. Kooiker
1Department of Pediatrics, University of California-Irvine, Irvine, CA, United States of America
2Department of Anatomy / Neurobiology, University of California-Irvine, Irvine, CA, United States of America
Manlin Shao
1Department of Pediatrics, University of California-Irvine, Irvine, CA, United States of America
2Department of Anatomy / Neurobiology, University of California-Irvine, Irvine, CA, United States of America
Benjamin G. Gunn
1Department of Pediatrics, University of California-Irvine, Irvine, CA, United States of America
2Department of Anatomy / Neurobiology, University of California-Irvine, Irvine, CA, United States of America
7Division of Neuroscience, Medical Research Institute, Dundee University, Ninewells Hospital and Medical School, Dundee, United Kingdom
Jaclyn Beck
2Department of Anatomy / Neurobiology, University of California-Irvine, Irvine, CA, United States of America
Xinglong Bai
1Department of Pediatrics, University of California-Irvine, Irvine, CA, United States of America
2Department of Anatomy / Neurobiology, University of California-Irvine, Irvine, CA, United States of America
Stephanie M. Law
1Department of Pediatrics, University of California-Irvine, Irvine, CA, United States of America
2Department of Anatomy / Neurobiology, University of California-Irvine, Irvine, CA, United States of America
Julie C. Savage
5Département de Médecine Moléculaire, Université Laval, Québec City, QC, Canada
6Axe Neurosciences, Centre de recherche du CHU de Québec, QC, Canada
Jeremy J. Lambert
7Division of Neuroscience, Medical Research Institute, Dundee University, Ninewells Hospital and Medical School, Dundee, United Kingdom
Delia Belelli
7Division of Neuroscience, Medical Research Institute, Dundee University, Ninewells Hospital and Medical School, Dundee, United Kingdom
Marie-Ève Tremblay
5Département de Médecine Moléculaire, Université Laval, Québec City, QC, Canada
6Axe Neurosciences, Centre de recherche du CHU de Québec, QC, Canada
Michael D. Cahalan
3Department of Physiology & Biophysics, University of California-Irvine, Irvine, CA, United States of America
Tallie Z. Baram
1Department of Pediatrics, University of California-Irvine, Irvine, CA, United States of America
2Department of Anatomy / Neurobiology, University of California-Irvine, Irvine, CA, United States of America
3Department of Physiology & Biophysics, University of California-Irvine, Irvine, CA, United States of America
Article usage
Posted July 22, 2021.
Impaired developmental microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons exacerbates stress responses throughout life
Jessica L. Bolton, Annabel K. Short, Shivashankar Othy, Cassandra L. Kooiker, Manlin Shao, Benjamin G. Gunn, Jaclyn Beck, Xinglong Bai, Stephanie M. Law, Julie C. Savage, Jeremy J. Lambert, Delia Belelli, Marie-Ève Tremblay, Michael D. Cahalan, Tallie Z. Baram
bioRxiv 2021.07.21.453252; doi: https://doi.org/10.1101/2021.07.21.453252
Impaired developmental microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons exacerbates stress responses throughout life
Jessica L. Bolton, Annabel K. Short, Shivashankar Othy, Cassandra L. Kooiker, Manlin Shao, Benjamin G. Gunn, Jaclyn Beck, Xinglong Bai, Stephanie M. Law, Julie C. Savage, Jeremy J. Lambert, Delia Belelli, Marie-Ève Tremblay, Michael D. Cahalan, Tallie Z. Baram
bioRxiv 2021.07.21.453252; doi: https://doi.org/10.1101/2021.07.21.453252
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