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Epithelial-mesenchymal plasticity determines estrogen receptor positive (ER+) breast cancer dormancy and reacquisition of an epithelial state drives awakening

Patrick Aouad, Yueyun Zhang, Céline Stibolt, Sendurai A. Mani, George Sflomos, View ORCID ProfileCathrin Brisken
doi: https://doi.org/10.1101/2021.07.22.453458
Patrick Aouad
1ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
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Yueyun Zhang
1ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
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Céline Stibolt
1ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
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Sendurai A. Mani
2Department of Translational Molecular Pathology, MD Anderson Cancer Center, Houston, Texas 77030
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George Sflomos
1ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
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Cathrin Brisken
1ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
3The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
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  • ORCID record for Cathrin Brisken
  • For correspondence: cathrin.brisken@epfl.ch
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Article Information

doi 
https://doi.org/10.1101/2021.07.22.453458
History 
  • July 26, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Patrick Aouad1,
  2. Yueyun Zhang1,
  3. Céline Stibolt1,
  4. Sendurai A. Mani2,
  5. George Sflomos1 and
  6. Cathrin Brisken1,3,*
  1. 1ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
  2. 2Department of Translational Molecular Pathology, MD Anderson Cancer Center, Houston, Texas 77030
  3. 3The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
  1. ↵*To whom correspondence should be addressed: Cathrin Brisken, MD, PhD ISREC - Swiss Institute for Experimental Cancer Research École Polytechnique Fédérale de Lausanne (EPFL), SV2.832 Station 19, CH-1015 Lausanne, Switzerland. E-mail: cathrin.brisken{at}epfl.ch
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Posted July 26, 2021.
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Epithelial-mesenchymal plasticity determines estrogen receptor positive (ER+) breast cancer dormancy and reacquisition of an epithelial state drives awakening
Patrick Aouad, Yueyun Zhang, Céline Stibolt, Sendurai A. Mani, George Sflomos, Cathrin Brisken
bioRxiv 2021.07.22.453458; doi: https://doi.org/10.1101/2021.07.22.453458
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Epithelial-mesenchymal plasticity determines estrogen receptor positive (ER+) breast cancer dormancy and reacquisition of an epithelial state drives awakening
Patrick Aouad, Yueyun Zhang, Céline Stibolt, Sendurai A. Mani, George Sflomos, Cathrin Brisken
bioRxiv 2021.07.22.453458; doi: https://doi.org/10.1101/2021.07.22.453458

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