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Biocompatible soft hydrogel lens as topical implants for diabetic retinopathy

View ORCID ProfileRajkumar Sadasivam, View ORCID ProfileGopinath Packirisamy, View ORCID ProfileMayank Goswami
doi: https://doi.org/10.1101/2021.07.23.453466
Rajkumar Sadasivam
aDivyadrishti Imaging laboratory, Department of Physics, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand-247667, India
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  • For correspondence: mayank.goswami@ph.iitr.ac.in rsadasivam@ph.iitr.ac.in
Gopinath Packirisamy
bNanobiotechnology laboratory, Department of Bioscience and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand-247667, India
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Mayank Goswami
aDivyadrishti Imaging laboratory, Department of Physics, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand-247667, India
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  • For correspondence: mayank.goswami@ph.iitr.ac.in rsadasivam@ph.iitr.ac.in
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Abstract

Fashioned contact lenses can be converted into novel drug delivery vehicles. Ocular disease like diabetic retinopathy is a major microvascular complication where its early diagnosis and treatment is still a mystery to clinicians. Delivery of pharmaceuticals to the posterior part of eye is quite difficult, with exemption from the injectable formulations. Drug loaded hydrogel like contact lens implants can be utilized in place of commercial contact lens. Such hydrogel lens implants are developed with precise manner in which they are to be inserted as implants in the mice models. The present work is the preliminary outcome of our ongoing research work where the polymerized lens implant can be used as payload carrier for retinopathy. The aim is to propose such appropriate implants suitable for in vivo mice models.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted July 23, 2021.
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Biocompatible soft hydrogel lens as topical implants for diabetic retinopathy
Rajkumar Sadasivam, Gopinath Packirisamy, Mayank Goswami
bioRxiv 2021.07.23.453466; doi: https://doi.org/10.1101/2021.07.23.453466
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Biocompatible soft hydrogel lens as topical implants for diabetic retinopathy
Rajkumar Sadasivam, Gopinath Packirisamy, Mayank Goswami
bioRxiv 2021.07.23.453466; doi: https://doi.org/10.1101/2021.07.23.453466

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