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Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state

Scott S. Bolkan, Iris R. Stone, Lucas Pinto, View ORCID ProfileZoe C. Ashwood, Jorge M. Iravedra Garcia, Alison L. Herman, Priyanka Singh, Akhil Bandi, Julia Cox, Christopher A. Zimmerman, Jounhong Ryan Cho, Ben Engelhard, View ORCID ProfileJonathan W. Pillow, Ilana B. Witten
doi: https://doi.org/10.1101/2021.07.23.453573
Scott S. Bolkan
1Princeton Neuroscience Institute; Princeton University; Princeton, NJ 08544; USA
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Iris R. Stone
1Princeton Neuroscience Institute; Princeton University; Princeton, NJ 08544; USA
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Lucas Pinto
1Princeton Neuroscience Institute; Princeton University; Princeton, NJ 08544; USA
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Zoe C. Ashwood
1Princeton Neuroscience Institute; Princeton University; Princeton, NJ 08544; USA
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  • ORCID record for Zoe C. Ashwood
Jorge M. Iravedra Garcia
1Princeton Neuroscience Institute; Princeton University; Princeton, NJ 08544; USA
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Alison L. Herman
1Princeton Neuroscience Institute; Princeton University; Princeton, NJ 08544; USA
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Priyanka Singh
1Princeton Neuroscience Institute; Princeton University; Princeton, NJ 08544; USA
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Akhil Bandi
1Princeton Neuroscience Institute; Princeton University; Princeton, NJ 08544; USA
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Julia Cox
1Princeton Neuroscience Institute; Princeton University; Princeton, NJ 08544; USA
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Christopher A. Zimmerman
1Princeton Neuroscience Institute; Princeton University; Princeton, NJ 08544; USA
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Jounhong Ryan Cho
1Princeton Neuroscience Institute; Princeton University; Princeton, NJ 08544; USA
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Ben Engelhard
1Princeton Neuroscience Institute; Princeton University; Princeton, NJ 08544; USA
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Jonathan W. Pillow
1Princeton Neuroscience Institute; Princeton University; Princeton, NJ 08544; USA
2Department of Psychology; Princeton University; Princeton, NJ 08544; USA
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  • ORCID record for Jonathan W. Pillow
Ilana B. Witten
1Princeton Neuroscience Institute; Princeton University; Princeton, NJ 08544; USA
2Department of Psychology; Princeton University; Princeton, NJ 08544; USA
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  • For correspondence: iwitten@princeton.edu
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Abstract

A classic view of the striatum holds that activity in direct and indirect pathways oppositely modulates motor output. Whether this involves direct control of movement, or reflects a cognitive process underlying movement, remains unresolved. Here we find that strong, opponent control of behavior by the two pathways of the dorsomedial striatum (DMS) depends on the cognitive requirements of a task. Furthermore, a latent state model (a hidden markov model with generalized linear model observations) reveals that—even within a single task—the contribution of the two pathways to behavior is state-dependent. Specifically, the two pathways have large contributions in one of two states associated with a strategy of evidence accumulation, compared to a state associated with a strategy of repeating previous choices. Thus, both the demands imposed by a task, as well as the internal state of mice when performing a task, determine whether DMS pathways provide strong and opponent control of behavior.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted January 10, 2022.
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Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state
Scott S. Bolkan, Iris R. Stone, Lucas Pinto, Zoe C. Ashwood, Jorge M. Iravedra Garcia, Alison L. Herman, Priyanka Singh, Akhil Bandi, Julia Cox, Christopher A. Zimmerman, Jounhong Ryan Cho, Ben Engelhard, Jonathan W. Pillow, Ilana B. Witten
bioRxiv 2021.07.23.453573; doi: https://doi.org/10.1101/2021.07.23.453573
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Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state
Scott S. Bolkan, Iris R. Stone, Lucas Pinto, Zoe C. Ashwood, Jorge M. Iravedra Garcia, Alison L. Herman, Priyanka Singh, Akhil Bandi, Julia Cox, Christopher A. Zimmerman, Jounhong Ryan Cho, Ben Engelhard, Jonathan W. Pillow, Ilana B. Witten
bioRxiv 2021.07.23.453573; doi: https://doi.org/10.1101/2021.07.23.453573

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