Transcriptomic Analysis of Human Sensory Neurons in Painful Diabetic Neuropathy Reveals Inflammation and Neuronal Loss

Bradford E. Hall; Emma Macdonald; Margaret Cassidy; Sijung Yun; Matthew R. Sapio; Pradipta Ray; Megan Doty; Pranavi Nara; Michael D. Burton; Stephanie Shiers; Abhik Ray-Chaudhury; Andrew J. Mannes; Theodore J. Price; Michael J. Iadarola; Ashok B. Kulkarni

doi:10.1101/2021.07.23.453576

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Transcriptomic Analysis of Human Sensory Neurons in Painful Diabetic Neuropathy Reveals Inflammation and Neuronal Loss

Bradford E. Hall, Emma Macdonald, Margaret Cassidy, Sijung Yun, View ORCID ProfileMatthew R. Sapio, Pradipta Ray, Megan Doty, Pranavi Nara, Michael D. Burton, Stephanie Shiers, Abhik Ray-Chaudhury, Andrew J. Mannes, Theodore J. Price, Michael J. Iadarola, Ashok B. Kulkarni

doi: https://doi.org/10.1101/2021.07.23.453576

Bradford E. Hall

1Functional Genomics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA

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Emma Macdonald

1Functional Genomics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA

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Margaret Cassidy

1Functional Genomics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA

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Sijung Yun

2Yotta Biomed, LLC, Bethesda, MD 20814, USA

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Matthew R. Sapio

3Department of Perioperative Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA

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ORCID record for Matthew R. Sapio

Pradipta Ray

4School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080

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Megan Doty

1Functional Genomics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA

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Pranavi Nara

3Department of Perioperative Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA

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Michael D. Burton

5Neuroimmunology and Behavior Group, School of Behavior and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080

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Stephanie Shiers

4School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080

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Abhik Ray-Chaudhury

6Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA

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Andrew J. Mannes

3Department of Perioperative Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA

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Theodore J. Price

3Department of Perioperative Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA

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Michael J. Iadarola

3Department of Perioperative Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA

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Ashok B. Kulkarni

1Functional Genomics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA

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For correspondence: ashok.kulkarni@nih.go

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Posted July 25, 2021.

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Transcriptomic Analysis of Human Sensory Neurons in Painful Diabetic Neuropathy Reveals Inflammation and Neuronal Loss

Bradford E. Hall, Emma Macdonald, Margaret Cassidy, Sijung Yun, Matthew R. Sapio, Pradipta Ray, Megan Doty, Pranavi Nara, Michael D. Burton, Stephanie Shiers, Abhik Ray-Chaudhury, Andrew J. Mannes, Theodore J. Price, Michael J. Iadarola, Ashok B. Kulkarni

bioRxiv 2021.07.23.453576; doi: https://doi.org/10.1101/2021.07.23.453576

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