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Structural and functional network-level reorganization in the coding of auditory motion directions and sound source locations in the absence of vision

View ORCID ProfileCeren Battal, View ORCID ProfileAne Gurtubay-Antolin, Mohamed Rezk, Stefania Mattioni, Giorgia Bertonati, Valeria Occelli, Roberto Bottini, Stefano Targher, Chiara Maffei, Jorge Jovicich, Olivier Collignon
doi: https://doi.org/10.1101/2021.07.28.454106
Ceren Battal
1Center of Mind/Brain Sciences, University of Trento, 38123, Trento, Italy
2Institute of Research in Psychology (IPSY) and in Neuroscience (IoNS), University of Louvain, 1348, Louvain-la-Neuve, Belgium
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  • ORCID record for Ceren Battal
  • For correspondence: ceren.battal@uclouvain.be ane.gurtubay@uclouvain.be olivier.collignon@uclouvain.be
Ane Gurtubay-Antolin
2Institute of Research in Psychology (IPSY) and in Neuroscience (IoNS), University of Louvain, 1348, Louvain-la-Neuve, Belgium
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  • For correspondence: ceren.battal@uclouvain.be ane.gurtubay@uclouvain.be olivier.collignon@uclouvain.be
Mohamed Rezk
1Center of Mind/Brain Sciences, University of Trento, 38123, Trento, Italy
2Institute of Research in Psychology (IPSY) and in Neuroscience (IoNS), University of Louvain, 1348, Louvain-la-Neuve, Belgium
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Stefania Mattioni
1Center of Mind/Brain Sciences, University of Trento, 38123, Trento, Italy
2Institute of Research in Psychology (IPSY) and in Neuroscience (IoNS), University of Louvain, 1348, Louvain-la-Neuve, Belgium
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Giorgia Bertonati
1Center of Mind/Brain Sciences, University of Trento, 38123, Trento, Italy
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Valeria Occelli
1Center of Mind/Brain Sciences, University of Trento, 38123, Trento, Italy
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Roberto Bottini
1Center of Mind/Brain Sciences, University of Trento, 38123, Trento, Italy
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Stefano Targher
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Chiara Maffei
3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 01129, USA
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Jorge Jovicich
1Center of Mind/Brain Sciences, University of Trento, 38123, Trento, Italy
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Olivier Collignon
1Center of Mind/Brain Sciences, University of Trento, 38123, Trento, Italy
2Institute of Research in Psychology (IPSY) and in Neuroscience (IoNS), University of Louvain, 1348, Louvain-la-Neuve, Belgium
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  • For correspondence: ceren.battal@uclouvain.be ane.gurtubay@uclouvain.be olivier.collignon@uclouvain.be
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Abstract

How does blindness affect the brain network supporting spatial hearing? We used a combined functional and diffusion MRI approach to study the impact of early blindness on the brain networks typically coding for audio-visual motion and location. Whole-brain functional univariate analysis revealed preferential response to auditory motion in a dorsal network including the planum temporale (hPT) as well as the anterior portion of the middle temporal cortex (hMT+/V5) in both sighted and congenitally blind participants (male and female). Blind participants showed additional preferential response to auditory motion in the posterior region of hMT+/V5. Importantly, multivariate decoding analysis revealed the presence of motion direction information that was higher in hMT+/V5 and lower in hPT of blind relative to sighted people. Decoding sound source location showed a similar pattern of results even if the decoding accuracies were in general lower than those obtained from motion directions. Diffusion MRI revealed that the macrostructure (trajectory and connectivity index) of hMT+/V5 – hPT connectivity did not differ between groups, while the microstructure of the connections was altered in blind people. These results suggest that early visual deprivation triggers a network-level reorganization that enhances the recruitment of occipital areas in conjunction with a release in the computational workload of temporal regions typically dedicated to spatial hearing. This functional reorganization is accompanied by white-matter microstructural alterations in related occipital-temporal connections.

Competing Interest Statement

The authors have declared no competing interest.

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Structural and functional network-level reorganization in the coding of auditory motion directions and sound source locations in the absence of vision
Ceren Battal, Ane Gurtubay-Antolin, Mohamed Rezk, Stefania Mattioni, Giorgia Bertonati, Valeria Occelli, Roberto Bottini, Stefano Targher, Chiara Maffei, Jorge Jovicich, Olivier Collignon
bioRxiv 2021.07.28.454106; doi: https://doi.org/10.1101/2021.07.28.454106
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Structural and functional network-level reorganization in the coding of auditory motion directions and sound source locations in the absence of vision
Ceren Battal, Ane Gurtubay-Antolin, Mohamed Rezk, Stefania Mattioni, Giorgia Bertonati, Valeria Occelli, Roberto Bottini, Stefano Targher, Chiara Maffei, Jorge Jovicich, Olivier Collignon
bioRxiv 2021.07.28.454106; doi: https://doi.org/10.1101/2021.07.28.454106

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