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Virtual screening for small molecule pathway regulators by image profile matching
View ORCID ProfileMohammad H. Rohban, View ORCID ProfileAshley M. Fuller, View ORCID ProfileCeryl Tan, Jonathan T. Goldstein, View ORCID ProfileDeepsing Syangtan, Amos Gutnick, Madhura P. Nijsure, View ORCID ProfileMegan Rigby, View ORCID ProfileJoshua R Sacher, View ORCID ProfileSteven M. Corsello, Grace B. Peppler, Marta Bogaczynska, View ORCID ProfileAndrew Boghossian, Gabrielle E. Ciotti, Ann DeVine, View ORCID ProfileMinh Doan, Jennifer P. Gale, Rik Derynck, Thomas Turbyville, View ORCID ProfileJoel D. Boerckel, View ORCID ProfileShantanu Singh, View ORCID ProfileLaura L. Kiessling, View ORCID ProfileThomas L. Schwarz, View ORCID ProfileXaralabos Varelas, View ORCID ProfileFlorence F. Wagner, Ran Kafri, T.S. Karin Eisinger-Mathason, View ORCID ProfileAnne E. Carpenter
doi: https://doi.org/10.1101/2021.07.29.454377
Mohammad H. Rohban
1Broad Institute of MIT and Harvard; Cambridge MA, USA; Department: Imaging Platform
Ashley M. Fuller
2Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine; Philadelphia, PA, USA
Ceryl Tan
3Department of Molecular Genetics, University of Toronto; Toronto, ON M5G 1A8, Canada
4Cell Biology, The Hospital for Sick Children; Toronto, ON M5G 0A4, Canada
Jonathan T. Goldstein
5Broad Institute of MIT and Harvard; Cambridge MA, USA; Department: Cancer Program
Deepsing Syangtan
6Massachusetts Institute of Technology, Cambridge; MA, USA; Department of Chemistry
Amos Gutnick
7FM Kirby Neurobiology Center, Boston Children’s Hospital; Boston, MA, USA
8Department of Neurobiology, Harvard Medical School; Boston, MA, USA
Madhura P. Nijsure
9Department of Orthopaedic Surgery & Bioengineering, University of Pennsylvania; Philadelphia, PA, USA
Megan Rigby
10Frederick National Laboratory for Cancer Research; Frederick, MD, USA
Joshua R Sacher
11Broad Institute of MIT and Harvard; Cambridge MA, USA; Department: Center for the Development of Therapeutics
Steven M. Corsello
5Broad Institute of MIT and Harvard; Cambridge MA, USA; Department: Cancer Program
12Department of Medical Oncology, Dana-Farber Cancer Institute; Boston, MA, USA
Grace B. Peppler
13Department of Biochemistry, Boston University School of Medicine; Boston, MA, USA
Marta Bogaczynska
14Departments of Cell/Tissue Biology and Anatomy, University of California; San Francisco, CA, USA
Andrew Boghossian
5Broad Institute of MIT and Harvard; Cambridge MA, USA; Department: Cancer Program
Gabrielle E. Ciotti
2Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine; Philadelphia, PA, USA
Ann DeVine
2Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine; Philadelphia, PA, USA
Minh Doan
1Broad Institute of MIT and Harvard; Cambridge MA, USA; Department: Imaging Platform
Jennifer P. Gale
11Broad Institute of MIT and Harvard; Cambridge MA, USA; Department: Center for the Development of Therapeutics
Rik Derynck
14Departments of Cell/Tissue Biology and Anatomy, University of California; San Francisco, CA, USA
Thomas Turbyville
10Frederick National Laboratory for Cancer Research; Frederick, MD, USA
Joel D. Boerckel
9Department of Orthopaedic Surgery & Bioengineering, University of Pennsylvania; Philadelphia, PA, USA
Shantanu Singh
1Broad Institute of MIT and Harvard; Cambridge MA, USA; Department: Imaging Platform
Laura L. Kiessling
6Massachusetts Institute of Technology, Cambridge; MA, USA; Department of Chemistry
Thomas L. Schwarz
7FM Kirby Neurobiology Center, Boston Children’s Hospital; Boston, MA, USA
8Department of Neurobiology, Harvard Medical School; Boston, MA, USA
Xaralabos Varelas
13Department of Biochemistry, Boston University School of Medicine; Boston, MA, USA
Florence F. Wagner
11Broad Institute of MIT and Harvard; Cambridge MA, USA; Department: Center for the Development of Therapeutics
Ran Kafri
3Department of Molecular Genetics, University of Toronto; Toronto, ON M5G 1A8, Canada
4Cell Biology, The Hospital for Sick Children; Toronto, ON M5G 0A4, Canada
T.S. Karin Eisinger-Mathason
2Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine; Philadelphia, PA, USA
Anne E. Carpenter
1Broad Institute of MIT and Harvard; Cambridge MA, USA; Department: Imaging Platform
Posted November 23, 2021.
Virtual screening for small molecule pathway regulators by image profile matching
Mohammad H. Rohban, Ashley M. Fuller, Ceryl Tan, Jonathan T. Goldstein, Deepsing Syangtan, Amos Gutnick, Madhura P. Nijsure, Megan Rigby, Joshua R Sacher, Steven M. Corsello, Grace B. Peppler, Marta Bogaczynska, Andrew Boghossian, Gabrielle E. Ciotti, Ann DeVine, Minh Doan, Jennifer P. Gale, Rik Derynck, Thomas Turbyville, Joel D. Boerckel, Shantanu Singh, Laura L. Kiessling, Thomas L. Schwarz, Xaralabos Varelas, Florence F. Wagner, Ran Kafri, T.S. Karin Eisinger-Mathason, Anne E. Carpenter
bioRxiv 2021.07.29.454377; doi: https://doi.org/10.1101/2021.07.29.454377
Virtual screening for small molecule pathway regulators by image profile matching
Mohammad H. Rohban, Ashley M. Fuller, Ceryl Tan, Jonathan T. Goldstein, Deepsing Syangtan, Amos Gutnick, Madhura P. Nijsure, Megan Rigby, Joshua R Sacher, Steven M. Corsello, Grace B. Peppler, Marta Bogaczynska, Andrew Boghossian, Gabrielle E. Ciotti, Ann DeVine, Minh Doan, Jennifer P. Gale, Rik Derynck, Thomas Turbyville, Joel D. Boerckel, Shantanu Singh, Laura L. Kiessling, Thomas L. Schwarz, Xaralabos Varelas, Florence F. Wagner, Ran Kafri, T.S. Karin Eisinger-Mathason, Anne E. Carpenter
bioRxiv 2021.07.29.454377; doi: https://doi.org/10.1101/2021.07.29.454377
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